Pharmacokinetics is a first, but essential step to improve population-tailored postoperative analgesia, also after Caesarean delivery. We therefore aimed to quantify the impact of caesarean delivery on the pharmacokinetics of intravenous (iv) paracetamol (2 g, single dose) and iv ketorolac tromethamine (30 mg, single dose) in 2 cohorts eachof 8 women at caesarean delivery and to compare these f...

Introduction Septorhinoplasty operates on cartilage and bone of the nose is ensued by severe postoperative pain. The objective this study to evaluate effects preoperative administration intravenous (IV) paracetamol ibuprofen pain scores in patients undergoing septorhinoplasty. Methodology 150 septorhinoplasty were randomly assigned into three groups with 50 each group. control group (Group A) w...

Excisional technique according to Milligan-Morgan remains the most effective approach for patients with grade III-IV hemorrhoids [1]. However, it is usually associated with significant postoperative pain that may result in severe patient discomfort and in a delayed return to daily activities. Pain seems to be multifactorial, depending on factors such as individual tolerance, method of anesthesi...

Material and methods: Sixty male patients (ASA I and II) undergoing varicocelectomy and testicular sperm extraction (TESE) with standard laryngeal mask airway (LMA) anesthesia were randomly divided into two groups. Patients in Group I (n=30) received 50 mg of dexketoprofen trometamol iv before induction, whereas patients in Group II (n=30) received saline. All patients received standard LMA ane...

BACKGROUND Video-assisted thoracic surgery (VATS) is a minimally invasive procedure that is growing more common around the world. Despite causing less pain compared open thoracic surgery, postoperative pain management is still important. OBJECTIVES The aim of the present study was to compare the analgesic effects of paracetamol and ketorolac in VATS patients. METHODS This was a double-blind...

AIM The aim of this paper was to investigate the intraocular pressure (IOP)-changing properties of a single standard dose of intravenous (IV) paracetamol and compare it to that of topical timolol, oral acetazolamide, and no treatment. METHODS A prospective, randomized, investigator-blind, parallel-group study was conducted in 73 eyes of 52 subjects. Subjects received a single dose of IV parac...

background pain following laparoscopy could be due to different causes requiring effective postoperative analgesia. objectives in the present study, we evaluated the combined effect of intraperitoneal infiltration of bupivacaine-meperidine versus intravenous infusion of paracetamol on pain relief after diagnostic gynecologic laparoscopy. conclusions intraperitoneal infiltration of bupivacaine w...

in the present work, the modified nickel electrode was electrochemically fabricated and tested for the electro-oxidation of paracetamol in alkaline media. the methods of cyclic voltammetry (cv), chronoamperometry (ca), and impedance spectroscopy (eis) were used to determine kinetic parameters such as transfer coefficient (α), the catalytic reaction rate constants (k), and the diffusion coeffici...

conclusions according to the results of the current study, postoperative analgesia in children was improved in the ketamine group. therefore, for better management of posttonsillectomy pain, low-dose ketamine administration with paracetamol is recommended. results there was no significant difference between the two groups considering demographic data (age, sex distribution, weight and height). ...

Background: Paracetamol, is the most widely used over-the-counter analgesic and antipyretic medication in world, which has minimal adverse effects at therapeutic dosages. But high doses causes hepatic damage oxidative stress. Objectives: The current study was designed to investigate paracetamol toxic upon liver stress after repeated oral dose evaluate possible protective effect of alpha lipoic ...