Blood transfusion has been identified as a source of human-to-human transmission of variant Creutzfeldt-Jakob disease. Three cases of variant Creutzfeldt-Jakob disease have been identified following red cell transfusions from donors who subsequently developed variant Creutzfeldt-Jakob disease and an asymptomatic red cell transfusion recipient, who did not die of variant Creutzfeldt-Jakob diseas...

Human prion diseases like Creutzfeldt-Jakob disease are infectious, inherited, or sporadic neurodegenerative disorders, characterized by the accumulation of an abnormal isoform of the host-encoded prion protein. This affects nervous tissue in sporadic Creutzfeldt-Jakob disease and, additionally, in lymphoid tissue in bovine spongiform encephalopathy-linked variant Creutzfeldt-Jakob disease. Exp...

OBJECTIVE To describe clinical features and diagnostic tests of the MM2 cortical subtype in sporadic Creutzfeldt-Jakob disease. METHODS Clinical symptoms, magnetic resonance imaging studies, electroencephalograms, and cerebrospinal fluid markers were studied in 12 patients with genetically and neuropathologically verified sporadic Creutzfeldt-Jakob disease. Histological findings were semiquan...

Cohen D, Kutlay E, Edwards J, Peltier A, Beydoun A. Sporadic Creutzfeldt–Jakob disease presenting with nonconvulsive status epilepticus. Epil Behav 2004;5:792–6. Fernandez-Torre JL. Nonconvulsive status epilepticus in Creutzfeldt– Jakob disease. Clin Neurophysiol 2006;117:1879–80. Hirsch LJ, Claassen J, Mayer SA, Emerson RG. Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs): a ...

BACKGROUND The value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic cases of Creutzfeldt-Jakob disease has been questioned. OBJECTIVE To illustrate the value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic Creutzfeldt-Jakob disease. METHODS Case report. RESULTS A patient with a history of 3 corneal transplantations exhibited the alien h...

A 52 year old man with Creutzfeldt-Jakob disease who received a cadaveric dura mater graft 99 months before the onset is reported. The prion protein gene was homozygous for methionine at the polymorphic codon 129. Neuropathological examination disclosed a panencephalopathic type of Creutzfeldt-Jakob disease which was characterised by severe involvement of the cerebral white matter and cerebellu...

The following is an overview of the emerging issue of handling the dead human body with Creutzfeldt-Jakob Disease. The purpose is to educate the reader to what the disease is and is not and to better prepare the funeral service professional cremationist to service clientele while protecting the public end employees of the crematory. Creutzfeldt-Jakob Disease (CJD) is a relatively new disease ha...

REPORTING INFORMATION • Class B: Report by the close of the next business day after the case or suspected case presents and/or a positive laboratory result to the local public health department where the patient resides. If patient residence is unknown, report to the local public health department in which the reporting health care provider or laboratory is located. • Reporting Form(s) and/or M...