AIMS To investigate the effect of Notch2 and Notch3 on cell proliferation and apoptosis of two trophoblast cell lines, BeWo and JAR. METHODS Notch2 and Notch3 expression in BeWo and JAR cells was upregulated or downregulated using lentivirus-mediated overexpression or RNA interference. The effect of Notch2 and Notch3 on cell proliferation was assessed by the CCK-8 assay. The effect of Notch2 ...

This article aims to describe the training and medical licensing system (uieop) for becoming a physician officer (uigwan) during Korea's Goryeo Dynasty (918-1392). In the Goryeo Dynasty, although no license was necessary to provide medical services to the common people, there was a licensing examination to become a physician officer. No other national licensing system for healthcare professiona...

Empirical evidence suggests infants can make inferences about uncertain future events using probabilistic data (Denison & Xu, 2010; Teglas et al., 2007). However, it is unclear if infants are using information about proportions to make these decisions. Infants were presented with population jars that contained large distributions of objects, and were tasked with deciding which of the two jars w...

Copying the whole of a library is one of the major types of reuse in software development. In Java, a single library archive file often contains other libraries it depends on, but users of the library hardly know about such inner libraries. Since reusing libraries is a black-box method, developers may combine some libraries without knowing that those libraries contain the same library inside in...

Growth of anaerobic bacteria in the AnaeroPack (Mitsubishi Gas Chemical America, Inc., New York, N.Y.) anaerobic atmosphere generation systems, both the AnaeroPack jar and pouch and the AnaeroPack in a GasPak jar were considered equivalent to or better than growth obtained in the corresponding GasPak jar or pouch system (Becton Dickinson Microbiology Systems, Cockeysville, Md.) for 89 (86%) of ...

At the initial phase of embryo implantation, the trophoblast of the blastocyst has to establish contact to the free surface of the uterine epithelial cells (UECs) and to adhere there. Adhesion to an apical plasma membrane is a very unusual phenomenon, and mechanisms involved are poorty understood. Determination of binding forces using atomic force spectroscopy demonstrated that formation of str...

At the turn of the century scholars of Egyptian art were startled by the appearance of life-size portrait heads in excavations at Gizeh, the site of a large necropolis of the Old Kingdom. Until their discovery it was considered an almost invariable rule that private sculpture of the period represented types, not individuals. The Sheikh el Beled and several other representations of individuals w...