The clinical course of children with IgM rheumatoid-factor-positive chronic arthritis closely resembles that of seropositive rheumatoid disease in adults. The frequency of HLA DR4 is known to be increased in adults with seropositive rheumatoid arthritis, but the first major report on childhood arthritis did not suggest a correlation, though only 8 seropositive cases were included. Fifty-two chi...

Juvenile rheumatoid arthritis (JRA) differs in many aspects from its adult counterpart (Edstrom, 1958); one of the differences is a low incidence of positive sero-reactions for rheumatoid factors (RF) in patients with JRA (Bywaters, Carter, and Scott, 1959; Sievers, Ahvonen, Aho, and Wager, 1963; Ansell, 1966). Although the agglutinating activity of RF was found in different classes of immunogl...

Chronic childhood arthritis affecting more than four joints during the first 6 months of disease is defined as polyarthritis.1,2 In the classification of the International League of Associations for Rheumatology (ILAR),2 polyarthritis is further categorized as rheumatoid factor (RF) negative if tests for RF are negative, and RF positive if RF is detected on two occasions at least three months a...

background: single-nucleotide polymorphism (snp) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (ptpn22) has been shown to be a risk factor for different autoimmune diseases. this study explored the association of 1858 c/t snp with rheumatoid arthritis (ra) and celiac disease (cd) in a region covering south-west of iran. methods: totally, 52 patients with cd, 120 patien...

We herewith report the rare case of a patient with juvenile rheumatoid arthritis who developed on 2 occasions the clinical picture of an isolated unilateral palsy of the inferior oblique muscle—Brown’s syndrome, following pregnancies, each time in a different eye. Although the eye is frequently involved in rheumatoid arthritis (RA), the Brown’s syndrome is seldom reported in literature with reg...

Family physicians commonly see children with musculoskeletal complaints, and often these complaints are related to sports injuries and physical activities that are a part of childhood.Juvenile rheumatoid arthritis is important in the differential diagnosis of a child with prolonged musculoskeletal complaints. The following case highlights the importance of a complete history and physical examin...

The introduction of corticosteroid therapy in rheumatoid arthritis was followed by reports of fractures, particularly vertebral, occurring in patients receiving such treatment. This paper reviews the incidence and types of fractures occurring in patients with juvenile rheumatoid arthritis who have attended this hospital during the past 12 years, a small number ofwhom have received steroid therapy.