Background. Antimalarial drug-resistant Plasmodium falciparum strains have been a major obstacle to the global efforts of controlling and eliminating malaria. The hope of reintroducing chloroquine for the treatment of uncomplicated malaria follows recent reports on decreases in the prevalence of chloroquine-resistant P. falciparum in several countries and recently, its total disappearance in Ma...

The pfcrt gene is a biomarker to determine the resistance of Plasmodium falciparum chloroquine and amodiaquine. When was switched ACT, it very likely that there will be an increase in wild type strains (pfcrt K76) due absence exposure chloroquine. Currently has not used for malaria treatment. aims this study were identify polymorphisms phylogenetic analysis isolates from patients Pesawaran Rege...

Abstract Plasmodium falciparum resistance to Chloroquine (CQ) is a significant cause of mortality and morbidity worldwide. There paucity documented data on the prevalence CQ-resistant mutant haplotypes Pfcrt Pfmdr1 genes from malaria-endemic war effected Federally Administered Tribal Areas Pakistan. The objective this study was investigate P. CQ-resistance in area. Clinical isolates were collec...

In Uganda, artemether-lumefantrine was introduced as an artemisinin-based combination therapy (ACT) for malaria in 2006. We have previously reported a moderate decrease ex vivo efficacy of lumefantrine Northern where we also detected artemisinin-resistant Plasmodium falciparum. Therefore, it is necessary to search candidate partner alternatives ACT. Here, investigated susceptibility four ACT dr...

Malaria in the China-Myanmar border region is still severe; local transmission of both falciparum and vivax malaria persists, and there is a risk of geographically expanding antimalarial resistance. In this research, the pfmdr1, pfcrt, pvmdr1, and K13-propeller genotypes were determined in 26 Plasmodium falciparum and 64 Plasmodium vivax isolates from Yingjiang county of Yunnan province. The pf...

BACKGROUND & OBJECTIVES High mortality and morbidity in sickle-cell disease has been associated with malaria infection especially in countries where chloroquine is used. Chloroquine resistance has been associated with the emergence of Pfcrt mutant genes. This study aimed at comparing the prevalence rate of Pfcrt T76 mutation in Plasmodium falciparum isolates from infected individuals with sickl...

OBJECTIVES The risk of malaria infection is increased during pregnancy, and many countries recommend chloroquine prophylaxis in pregnant women, despite Plasmodium falciparum chloroquine resistance. Chloroquine resistance is associated with the pfcrt gene K76T mutation. The aim of this study was to compare the prevalence rate of pfcrt T76 mutation in P. falciparum isolates from infected pregnant...