Drug-resistance acquisition through kinase gate-keeper mutations is a major hurdle in the clinic. Here, we determined the first crystal structures of the human FGFR4 kinase domain (FGFR4K) alone and complexed with ponatinib, a promiscuous type-2 (DFG-out) kinase inhibitor, and an oncogenic FGFR4K harboring the V550L gate-keeper mutation bound to FIIN-2, a new type-1 irreversible inhibitor. Rema...

We propose a theory of how the speech gesture determines change in a functionally relevant variable of vocal tract state (e.g., constriction degree). A core postulate of the theory is that the gesture determines how the variable evolves in time independently of any executive time-keeper. That is, the theory involves intrinsic timing of speech gestures. We compare the theory against others in wh...

Clinical and research practices designed by developed countries are often implemented in host nations of the Third World. In recent years, a number of papers have presented a diversity of arguments to justify these practices which include the defence of research with placebos even though best proven treatments exist; the distribution of drugs unapproved in their country of origin; withholding o...

Introduction: 1. This sermon logically and chronologically follows a sermon entitled, " Blood Is Thicker than Blood. " 2. That sermon exalts the precious bonds saints have in the family of God and in their own local churches. 3. This sermon identifies the great blessing and duties of fulfilling our roles in our local congregations. 4. Attending church to sing, hear a sermon, and then go home is...

Floating emissive probe plasma potential data are presented over a two-dimensional array of locations in the discharge chamber of a 40-cm diameter ring-cusp ion thruster. The data rule out the presence of a potential-hill plasma structure downstream of the discharge cathode assembly (DCA), which has been proposed as a mechanism of high-energy ion formation leading to DCA erosion. The discharge ...

Arvand is the name of robots specially designed and constructed by sharif CE team for playing soccer according to RoboCup rules and regulations for the middle size robots. Two diierent types of robots are made, players and the goal keeper. A player robot consists of three main parts: mechanics (motion mechanism and kicker), hardware (image acquisition, processing unit and control unit) and soft...

This paper reports field results of E-PERMS in both (lie S-Chamber and their keeper caps. Hie results have been compiled during the past two years covering over 5,000 measurements. Data has been grouped to show precision (co-located tests), accuracy (radon chamber results), and electret stability. The latter results were also broken down into S-Chamber versus keeper cap versus electret series. ...

This paper presents dynamic standby control (DSC) with voltage keeper for further standby power reduction. As compared to the reported DSC, the new modified DSC can be kept deeply cut-off with negative overdrive voltage as well. Besides, a bootstrapped voltage keeper directly recharges the boosted node of power gate, which prevents leakage current during the recharging period. However, total st...