In this study, selenocystine, a nutritionally available selenoamino acid, was identified for the first time as a novel agent with anti proliferative activity on human keloids. The 20 μM concentration after 48 h treatment used here was the most effective to reduce keloid fibroblast growth. We analyzed the gene expression profile of selenocystine treatment response in keloid fibroblasts by the mi...

Keloids are a manifestation of a fibroproliferative scarring disorder of the skin and develop in response to dermal injury in patients with a susceptible background. Local, systemic, and genetic factors contribute to keloid susceptibility. These factors include tension on the edges of the wound, hormonal influences, and ethnicity, respectively. Castleman's disease is a rare lymphoproliferative ...

Background: Keloids are benign fibrous dermal tumors origina ng from skin injury a er surgery, piercing or others wounds. Materials and Methods: Sixty -two pa ents with keloids were treated postopera vely using orthovoltage irradia on. The total dose delivered was 12 Gy in three consecu ve days, 4Gy per frac on. Treatment started 24 h a er surgery. The median follow-up was 44.5 months. Results:...

Although therapeutic management of hypertrophic scars and keloids using contact or spray cryosurgery has yielded significant improvement or complete regression of hypertrophic scars and keloids, it requires one to 20 treatment sessions. This study was designed to assess the clinical safety and efficacy of an intralesional needle cryoprobe method in the treatment of hypertrophic scars and keloid...

BACKGROUND Depending on the cause, 40-90% of every deep dermis insult ends up in scar formation. Several modalities have been suggested as a treatment but a high rate of recurrence is reported in most of those interventions. High dose radiotherapy has been shown to be effective in reducing the recurrence rate. This study tried to determine the effectiveness of low dose rate radiotherapy follow...

Keloids are hypertrophic and proliferating pathological scars extending beyond the initial lesion without any tendency to regression. Usually, keloids consideredand treated as a single entity but clinical observations suggest heterogeneity in keloid morphologies with distinction of extensive nodular entities. Within keloid, could also be detected between superficial deep dermis or center periph...

BACKGROUND AND OBJECTIVES Differences in morphology of auricular keloids possibly contribute to distinct results of treatment. The aim of this study was to evaluate clinical characteristics of the auricular keloids according to the modified Chang-Park classification and to compare the results of treatment including recurrence rate between the subgroups. SUBJECTS AND METHODS Clinical data of 1...

INTRODUCTION Keloids are abnormal growths of fibrous tissue often seen on dark skin. We studied their clinical, epidemiological and therapeutic aspects in 456 consecutive cases. PATIENTS AND METHODS This retrospective study covering a 20-year period describes and analyzes all patients seen for keloids during that period. RESULTS The age range of 15-24 year-olds was affected most often (35.7...

Excess scar formation secondary to traumatic or surgical injuries can have devastating consequences, ranging from body disfigurement to organ dysfunction. Hypertrophic scars and keloids are skin fibrotic conditions that can be caused by minor insults to skin, such as acne or ear piercing, or by severe injuries such as burns. Differences between keloids, hypertrophic scars and normal scars inclu...

BACKGROUND Keloids are common benign tumors of the dermis, typically arising after insult to the skin. While typically only impinging on cosmesis, large or recurrent keloids may require therapeutic intervention. While no single standardized treatment course has been established, several series report excellent outcomes for keloids with post-surgery radiation therapy. CASE PRESENTATION We pres...