Information concerning the developmental mechanisms involved in skin differentiation have been mainly derived from in vitro experiments. We have previously observed that 6-day chick embryonic thigh skin keratinizes in vitro in chicken serum-containing medium, but does not do so in chick embryo extract-containing medium. This system seems adequate in many respects for investigating the mutual re...

BACKGROUND Nodular squamous cell carcinoma (SCC) and keratoacanthoma (KA) may mimic a variety of other benign and malignant non-pigmented nodules. OBJECTIVES To analyze the dermoscopic characteristics of nodular SCC and KA. PATIENTS/METHODS Retrospective analysis of 50 nodular SCCs and 8 KAs collected from a tertiary dermatology referral center and a private dermatology practice in Melbourn...

Corresponding author: Che-Hao Hsu, Department of Dermatology, Cathay General Hospital, 280 Jen-Ai Rd., Sec. 4, Taipei, Taiwan TEL: 886-2-27082121 FAX: 886-2-27074949 E-mail: [email protected] Funding source: none Confl ict of interest: none declared CASE REPORT A 45-year-old man presented with an asymptomatic, slowly growing, keratotic nodule on his left fl ank for one year. Physical examin...

The major structural proteins of epithelia, the keratins, and the keratin filament-associated protein, filaggrin, were analyzed in more than 50 samples of human embryonic and fetal skin by one-dimensional SDS PAGE and immunoblotting with monoclonal and polyclonal antibodies. Companion samples were examined by immunohistochemistry and electron microscopy. Based on structural characteristics of t...

Objectives. The habit of khat chewing is prevalent in many Middle Eastern and African cultures and has been associated with various adverse conditions in humans. This study aimed to describe histological changes induced by chronic khat chewing on the buccal mucosa. Methods. Biopsies of the buccal mucosa from 14 chronic khat chewers, 20 chronic khat chewers who also smoked tobacco, and 8 nonchew...