Objective: To compare the frequency of opioid requirement, after intravenous lignocaine infusion and ketorolac tromethamine in upper limb surgeries.
 Study Design: Quasi-experimental study.
 Place Duration Study: Combined Military Hospital, Lahore Pakistan, from Oct 2017 to Apr 2018.
 Methodology: ASA I/II patients either gender undergoing surgery were included. Patients randomly...

Two simple and rapid spectrophotometric methods were developed for the determination of two binary mixtures: moxifloxacin hydrochloride (MFH) with ketorolac tromethamine (KTM) and ciprofloxacin hydrochloride (CFH) with dexamethasone sodium phosphate (DSP). The first method, zero-crossing derivative spectrophotometry, depends on measuring the second derivative peak and trough values at 304 nm an...

The purpose of this study was to determine whether intravenous ketorolac tromethamine could produce preemptive analgesia in patients undergoing laparoscopic gynecologic surgical procedures. Each patient's response to pain was measured by the mechanical visual analogue scale (M-VAS) and total analgesic use. By using a double-blind design, 49 patients were randomized into the preemptive group (n ...

OBJECTIVES To determine if nonsteroidal anti-inflammatory drugs provide adequate pain control for patients having laparoscopic hernia repair and to compare the effectiveness of ketorolac tromethamine with ibuprofen in reducing postoperative laparoscopic hernia pain. DESIGN AND SETTING Prospective double-blind randomized study at a 100-bed community hospital. PATIENTS Seventy patients rangin...

Passive muscle stretch performed during a period of post-exercise muscle ischemia (PEMI) increases muscle sympathetic nerve activity (MSNA), and this suggests that the muscle metabolites may sensitize mechanoreceptors in healthy humans. However, the responsible substance(s) has not been studied thoroughly in humans. Human and animal studies suggest that cyclooxygenase products sensitize muscle ...

We have compared the renal effects of ketorolac trometamol 10 mg administered 4-hourly by intermittent i.m. injection or by continuous i.m. infusion with placebo in a double-blind study in 67 patients who had undergone upper abdominal surgery. Ketorolac was supplemented during the 48-h postoperative study period with bolus doses of morphine delivered by a patient controlled analgesia system. Th...

BACKGROUND Drug disposition is altered by pregnancy and the peripartum period but data on intravenous ketorolac pharmacokinetics following caesarean delivery have not been previously reported. METHODS At the end of caesarean delivery, women received an intravenous bolus of ketorolac tromethamine 30 mg (immediate postpartum, Group IP). Plasma samples were collected at 1, 2, 4, 6 and 8h. A simi...

Although dose-response curves are commonly used to describe in vivo cutaneous α-adrenergic responses, modeling parameters and analyses methods are not consistent across studies. The goal of the present investigation was to compare three analysis methods for in vivo cutaneous vasoconstriction studies using one reference data set. Eight women (22 ± 1 yr, 24 ± 1 kg/m(2)) were instrumented with thr...

PURPOSE Nonselective cyclooxygenase (COX) inhibitors have been reported to decrease the frequency of upper aerodigestive cancers. Ketorolac tromethamine oral rinse has been shown to resolve another COX-dependent process, periodontal disease, without incurring gastrointestinal side effects. This trial evaluated if a topically delivered oral rinse containing ketorolac was as safe as and more effe...