Large numbers of drugs are used in the treatment of hypertension and Calcium Channel Blockers are an important group among them. Cilnidipine is a new calcium channel blocking drug distinguished from other L-type calcium channel blockers with additional N-type of calcium channel blocking property. Cardioprotective, renoprotective and neuroprotective action of cilnidipine can provide additional b...

We have synthesized a novel series of 18 dialkyl 1,4-dihydro-4-(2'alkoxy-6'-pentadecylphenyl)-2,6-dimethyl-3,5 pyridine dicarboxylates from anacardic acid, a natural compound found in cashew nut shells, and investigated their blocking action on L- and T-type calcium channels transiently expressed in tSA-201 cells. The IC(50) values for L-type calcium channel block obtained with the series range...

introduction: the ionic currents show nonlinear behavior and electrical stimuli can influence their activation and inactivation kinetics. the time constant of depolarizing or hyperpolarizing current pulses has an important role in the firing behavior of neurons. in the present study, the effects of quasitrpezoidal command potentials on l-type calcium channel of somata of f1 neuron in helix aspe...

BACKGROUND/AIMS Arachidonic acid (AA) and its metabolites are important endogenous lipid messengers. In this study, we test the effect of Leukotriene B4 (LTB4), a 5-lipoxygenase metabolite of AA, on L-type calcium channels in A7r5 rat aortic vascular smooth muscle cells. METHODS L-type calcium channel currents were recorded by a patch-clamp technique. The mRNA expression of CaV1.2 was determi...