نتایج جستجو برای: l29
تعداد نتایج: 106 فیلتر نتایج به سال:
Adopting a person-centred approach, we integrate the job demands-control-support model with relational work design theory to investigate employee profiles involving autonomy, workload, social support and prosocial characteristics (representing combined influence of task significance beneficiary contact). For sample Australian not-for-profit employees ( N = 2421), identified four profiles: ‘acti...
We analyze the effect of committee formation on how corporate boards perform two main functions: setting CEO pay and overseeing the financial reporting process. The use of performance-based pay schemes induces the CEO to manipulate earnings, which leads to an increased need for board oversight. If the whole board is responsible for both functions, it is inclined to provide the CEO with a compen...
Here we investigate the effects of expressing an activated mutant of Notch (ICD-E) in an inducible transgenic mouse model. Hepatic expression of ICD-E in adult animals has no detectable phenotype, but simultaneous induction of ICD-E in both the liver and small intestine results in hepatic steatosis, lipogranuloma formation and mild insulin resistance within 96 hours. This supports work that sug...
The SecY complex associates with the ribosome to form a protein translocation channel in the bacterial plasma membrane. We have used cryo-electron microscopy and quantitative mass spectrometry to show that a nontranslating E. coli ribosome binds to a single SecY complex. The crystal structure of an archaeal SecY complex was then docked into the electron density maps. In the resulting model, two...
Nucleotide changes occurring in class I mutants of the /ao promoter have been determined. Mutants L8, L37, L65 and L592 produce a G. C to T-A transition at nucleotide 19, while L29, L146 and L614 produce a C 'G to A.T transition at nucleotide 28. These two mutational sites are symmetrically located in a sequence in which 12 of 14 nucleotides are related by a dyad axis. This region may be the bi...
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