نتایج جستجو برای: laboratory study
تعداد نتایج: 4150718 فیلتر نتایج به سال:
Neuronal excitability of the brain and ongoing homeostasis depend not only on intrinsic neuronal properties, but also on external environmental factors; together these determine the functionality of neuronal networks. Homeostatic factors become critically important during epileptogenesis, a process that involves complex disruption of self-regulatory mechanisms. Here we focus on the bioenergetic...
Why do we grow up to have the traits we do? Most 20th century scientists answered this question by referring only to our genes and our environments. But recent discoveries in the emerging field of behavioral epigenetics have revealed factors at the interface between genes and environments that also play crucial roles in development. These factors affect how genes work; scientists now know that ...
Collecting and analysing all available literature before starting an animal experiment is important and it is indispensable when writing a systematic review (SR) of animal research. Writing such review prevents unnecessary duplication of animal studies and thus unnecessary animal use (Reduction). One of the factors currently impeding the production of 'high-quality' SRs in laboratory animal sci...
The authors' jobs in Shell involve responsibility for the analytical activity which includes about 220 people at the central research laboratory and roughly another 50 or so in quality control laboratories at various plants and refineries. Because it is a rapidly evolving technology, the chemists' arsenal of analytical methods continues to change (figure 2). Figure 2 represents the authors' exp...
the online Data Supplement). The fetal-specific allele was positively detected in 36 of the 41 SABER analyses in which the fetal genotype was informative (Table 1). When applied as a panel, the assays were able to detect the presence of the paternally inherited, fetal-specific allele in at least one of the informative SNPs in all of the cases (Table 1). There was no false-positive detection. In...
Postal questionnaires offer an efficient method of collecting information. They are cheap and relatively quick and can be widely scattered geographically. In approaching professional groups there are no problems of illiteracy or inarticulateness to set against these advantages. The main difficulty then is often the response rate. With general practitioners the problem of response is often thoug...
BACKGROUND Many point of care diagnostic technologies are available which produce results within minutes, and offer the opportunity to deliver acute care out of hospital settings. Increasing access to diagnostics at the point of care could increase the volume and scope of acute ambulatory care. Yet these technologies are not routinely used in many settings. We aimed to explore how point of care...
The dataset we will be using is a genome-wide association study of gender (Vawter et al., 2004). In this study, samples were taken postmortem from the brains of 10 individuals, 5 men and 5 women. Three samples were taken from different regions of the brain of each individual, and one aliquot of each sample was sent to each of 3 laboratories for analysis. There were two different microarray plat...
BACKGROUND More widespread use of emergency contraception could help to reduce the number of unwanted pregnancies. AIM The objective of this study was to assess women's knowledge of emergency contraception. METHOD A questionnaire was distributed to 1290 women aged between 16 and 50 years attending 14 general practice surgeries in London over a two-week period in 1990. RESULTS The response...
During the last several years, high-density genotyping SNP arrays have facilitated genome-wide association studies (GWAS) that successfully identified common genetic variants associated with a variety of phenotypes. However, each of the identified genetic variants only explains a very small fraction of the underlying genetic contribution to the studied phenotypic trait. Moreover, discordance ob...
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