Angiogenesis and osteogenesis coupling processes are essential for bone regeneration, and human bone marrow stromal cells (hBMSCs) along with endothelial cells (ECs) are crucial participants. Deferoxamine (DFO), a hypoxia-mimetic agent, could activate the hypoxia-inducible factor (HIF)-1α signaling pathway and trigger angiogenic and osteogenic effects in these cells. However, the lifetime of DF...

     In this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (PLGA 50:50) and poly (lactide). The effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation effic...

Biodegradable controlled-release microsphere systems made with the biocompatible biodegradable polyester excipient poly [DL lactide-co-glycolide] constitute an exciting new technology for drug delivery to the central nervous system (CNS). The present study describes functional observations indicating that implantation of dopamine (DA) microspheres encapsulated within two different polymer excip...

The influence of copolymer composition on Poly(Lactide-co-Glycolide)/nanohydroxyapatite (PLGA/nHA) composite scaffolds is studied in the context of bone tissue engineering and regenerative medicine. The composite scaffolds are fabricated by thermally-induced phase separation and the effect of bioactive nanoparticles on their in vitro degradation in phosphate-buffered solution at 37 °C is analyz...

Background Therapeutic management of Mycobacterium avium infection is inadequate due to patient non-compliance, lengthy treatment regimen, multidrug associated toxic side-effects etc. particularly in AIDS patients who are at a greater risk of developing mycobacterial infection. This study was designed to evaluate chemotherapeutic potential of poly D, L-lactide-co-glycolide nanoparticles against...

Recently, polymeric nanoparticles (NPs) have attracted enormous attention as targeted drug delivery vehicles.[1-4] Especially, biodegradable and biocompatible polymeric NPs comprised of poly(lactide-co-glycolide)-b-polyethyleneglycol (PLGA-PEG) block copolymers exhibit optimal physicochemical characteristics such as the ability to incorporate various targeting agents, enhanced immune evasion, c...

A facile preparation of polystyrene-block-poly(lactide-co-glycolide) PS-b-PLGA block copolymers was reported in detail. Well-defined were successfully obtained via living anionic polymerization and ring-opening polymerization. First, hydroxyl-terminated linear polystyrenes prepared by The resulting polymers used as macroinitiators for copolymerization lactide glycolide the presence 1,8-diazabic...

The purposes of this research were to synthesize and characterize star-shaped poly lactide-co-glycolide-β-cyclodextrin (PLGA-β-CD) copolymer by reacting L-lactide, glycolide and β-cyclodextrin in the presence of stannous octoate as a catalyst. The structure of PLGA-β-CD copolymer was confirmed with 1H-NMR, 13C-NMR and FT-IR spectra. Albumin as a model peptide drug was encapsulated within nanopa...

*Correspondence: R. M. Mainardes. Departamento de Farmácia. Laboratório de Nanotecnologia Farmacêutica. Universidade Estadual do Centro-Oeste – UNICENTRO. Rua Simeão Camargo Varela de Sá, 03 85040-080 Guarapuava – PR, Brasil. E-mail: [email protected] A stability-indicating HPLC-PDA method for the determination of ferulic acid in chitosan-coated poly(lactide-co-glycolide) nanoparticles