The fascination of comparative ophthalmology lies in the amazing similarity between the eyes of very divergent species. Yet there are small but significant anatomical, physiological and pathobiological differences between the familiar eyes of the dog and cat and those of the rabbit, guinea pig, mouse and rat which have substantial implications for the treatment of ophthalmic conditions in these...

Myxoma virus (MV) is a candidate for oncolytic virotherapy due to its ability to selectively infect and kill tumor cells, yet MV is a species-specific pathogen that causes disease only in European rabbits. To assess the ability of MV to deliver cytokines to tumors, we created an MV (vMyxIL-12) that expresses human interleukin-12 (IL-12). vMyxIL-12 replicates similarly to wild-type MV, and virus...

Coronaviruses are closely monitored in the context of emerging diseases and, as illustrated with Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle East Respiratory Syndrome-coronavirus (MERS-CoV), are known to cross the species barrier and eventually to move from wildlife to humans. Knowledge of the diversity of coronaviruses in wildlife is therefore essential to better unders...

The occurrence of the genus Prolagus Pomel, 1853, in North Africa provides some strongest evidence for existence faunal exchanges between Europe and Africa. oldest African remains have been reported from Messinian locality Afoud Aït Kandoula Basin (6.2 Ma), identified during previous studies as species michauxi López-Martínez, 1975. Dental material already analyzed AF12-1 AF12-2 levels new coll...

The epidemiology of tularemia has influenced, perhaps incorrectly skewed, our views on the ecology of the agent of tularemia. In particular, the central role of lagomorphs needs to be reexamined. Diverse observations, some incidental, and some that are more generally reproducible, have not been synthesized so that the critical elements of the perpetuation of Francisella tularensis can be identi...