Cobalt(ll), copper(ll), nickel(ll) and zinc(ll) metal complexes of 2-carboxybenzylidene thienoylhydrazide HL(1) and 2-carboxybenzylidene furenoylhydrazide HL(2) of the type [M(L)(2).Cl(2)] have been prepared where M = Co(ll) and Ni(ll) and L = HL(1) and HL(2) (Fig 1) and characterized by their physical, analytical and spectral studies. The different mode of chelation of the ligands with metals ...

PURPOSE The goals of this study were to examine the expression of the antimicrobial peptide LL-37 in the corneal epithelium during wound healing and to investigate whether LL-37 stimulates human corneal epithelial cell (HCEC) migration, proliferation, and cytokine production. METHODS Expression of LL-37 was determined by RT-PCR and immunostaining in tissue sections and HCECs scraped from corn...

J. Z. Bai, (Jl 0. Bardon, <6> R. A. Becker-Szendy, <7> T. H. Burnett, (JOl J. S. Campbell, <9> S. J. Chen, (I} S. M. Chen,<)} Y. Q. Chen, H. C. Cui, (I) X. Z. Cui,< 1> H. L. Ding, (Jl Z. Z. Du, (Jl W. Dunwoodie, <7> C. Fang, (I) M. J. Fero, <6> M. L. Gao, (Jl S. Q. Gao, (J} W. X. Gao, (I} Y. N. Gao,< 1> J. H. Gu,(l} S.D. Gu,(l} W. X. Gu,(l} Y....

Cathelicidin LL-37 is one of the few human bactericidal peptides with potent antistaphylococcal activity. In this study we examined the susceptibility of LL-37 to proteolytic degradation by two major proteinases produced by Staphylococcus aureus, a metalloproteinase (aureolysin) and a glutamylendopeptidase (V8 protease). We found that aureolysin cleaved and inactivated LL-37 in a time- and conc...

Actin exists as a monomer (G-actin) which can be polymerized to filaments) F-actin) that under the influence of actin-binding proteins and polycations bundle and contribute to the formation of the cytoskeleton. Bundled actin from lysed cells increases the viscosity of sputum in lungs of cystic fibrosis patients. The human host defense peptide LL-37 was previously shown to induce actin bundling ...

Human LL-37 is a multifunctional antimicrobial peptide of cathelicidin family. It has been shown in recent studies that it can serve as a host's defense against influenza A virus. We now demonstrate in this study how signal peptide LL-37 (SP-LL-37) can be used in rice resistance against bacterial leaf blight and blast. We synthesized LL-37 peptide and subcloned in a recombinant pPZP vector with...

Preparation, ligational and biological properties of some pyrazinedicarboxaimide derived furanyl, thienyl and pyrrolyl compounds with Co(ll), Cu(ll), Ni(ll) and Zn(ll) metals are described. Magnetic moments, electronic, infrared, nuclear magnetic resonance spectra and elemental analysis data indicate that co-ordination of the ligands with the metal ions take place through the pyrazine ring nitr...

A retrospective study aims to explore differences in spinopelvic sagittal alignment between thoracolumbar disc herniation (TLD) and lower lumbar disc herniation (LLD).A total of 185 patients included 26 with TLD and 129 with LLD and 30 asymptomatic volunteers in normal group (NG). Each individual took full spine X-ray to evaluate pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), lumba...

The use of the diamine rac-trans-1,2-diaminocyclohexane (LL) as a major component of the solvent system allows the isolation of crystalline silver complexes with higher ratios of LL to silver (up to 4 : 1, compared to the previously obtained 1 : 1 in ethanolic solution). The complexes obtained and crystallographically characterized were (LL)2AgNO3 (1), (LL)3Ag(OAc)(H2O)2 (2) and (LL)4AgBr(H2O)3...