Each cell hosts thousands of proteins that vary greatly in abundance, structure, and chemical properties. To ensure that all proteins are biologically active and properly localized, efficient quality control systems have evolved. While the structure, function, and regulation of some individual protein folding factors and proteases were resolved up to atomic resolution, others remain poorly char...

This study investigated the dose-dependent response in lamb meat of stable nitrogen isotope ratio to the dietary proportion of legumes, and the ability of the nitrogen isotope signature of the meat to authenticate meat produced from legume-rich diets. Four groups of nine male Romane lambs grazing a cocksfoot pasture were supplemented with different levels of fresh alfalfa forage to obtain four ...

In Escherichia coli secreted proteins must be maintained in an export-competent state before translocation across the cytoplasmic membrane. This function is carried out by a group of proteins called chaperones. SecB is the major chaperone that interacts with precursor proteins before their secretion. We report results indicating that the DnaK and DnaJ heat shock proteins are also involved in th...

BACKGROUND There is insufficient evidence to support visceral leishmaniasis (VL) treatment recommendations in Brazil and an urgent need to improve current treatments. Drug combinations may be an option. METHODS A multicenter, randomized, open label, controlled trial was conducted in five sites in Brazil to evaluate efficacy and safety of (i) amphotericin B deoxycholate (AmphoB) (1 mg/kg/day f...

Lamb waves are frequently used in nondestructive evaluation and are proposed for structural health monitoring applications. While many numerical methods to obtain dispersion curves for Lamb waves have been developed and implemented, in general they are time consuming and do not lend themselves to analyses involving the perturbation of parameters such as the small thickness and wave speed change...

Spoilage of meat has remained a serious challenge in developing countries. The objective of this study was to evaluate the beef and lamb meat quality from supermarkets and shops in summer and winter season. Beef and lamb meat were stored at 4±1 o C during 5 days and test for microbiological properties, oxidation stability, and color properties, in beef and lamb meat. Samples were collected from...

The number of lambs sold per ewe mated in the breeding flock has a considerable impact on sheep operation profitability. This depends primarily on fertility, prolificacy (# of lambs), and lamb survival, mothering ability, milk production of the ewe and lamb growth rate. Optimal reproduction does vary by environment and management system – some sheep operations don’t want a lambing rate over 200...

Data on antifungal prophylaxis in paediatric cancer patients at high risk for invasive fungal disease (IFD) are scant. Intermittent administration of liposomal amphotericin B (LAMB) has been shown to be safe and effective in adult patients with haematological malignancies. We prospectively evaluated the safety and efficacy of prophylactic LAMB at a dosage of 2.5 mg/kg twice weekly in children a...

Body condition was scored at lambing (BCSL) on 101 mature (4 to 7 yr old) Polypay ewes and related to colostral immunoglobulin G (IgG) concentration and lamb performance. Colostrum samples were collected from each ewe within 12 h of lambing and litters of more than two lambs were reduced to two within 2 h of lambing. Colostral IgG concentrations decreased rapidly with time (b = -3.28; R2 = .213...

Adhesively bonded joints between metallic and composite plates are gaining increasing acceptance in safety critical applications such as automotive and aerospace structures. Lamb wave methods have considerable potential for the inspection of adhesive joints and assemblies for two reasons: they do not require direct access to the bond region, and they are much more amenable to rapid scanning tha...