Monotonic, multi-step and cyclic short beam shear tests were conducted on 2D and 3D woven composites. The test results were used to determine the effect of z-yarns on the inter-laminar shear strength as well as the multi-loading behavior. The presence of z-yarns was found to affect not only the inter-laminar shear strength of the composite but also the behavior of the composite beyond the elast...

One of the striking features of vascular endothelium, the single-cell-thick lining of the cardiovascular system, is its phenotypic plasticity. Various pathophysiologic factors, such as cytokines, growth factors, hormones, and metabolic products, can modulate its functional phenotype in health and disease. In addition to these humoral stimuli, endothelial cells respond to their biomechanical env...

A numerical investigation of Newtonian and non-Newtonian steady blood flow in a complete idealized threedimensional venous model have recently been shown to provide prognostically relevant for hemodynamic data. The geometry reconstruction is essencial for the assessment of clinically relevant hemodynamic parameters. The blood flow patterns influence the development of thrombus that remains a si...

Bedload transport generally depends on the bed shear stress and Reynolds number. Many studies conducted for the condition of turbulent flows have revealed the dependence of the transport rate on the bed shear stress, while knowledge of the Reynolds number effect on the transport rate is very limited. As an extreme case to reflect the viscous effect on sediment transport, sediment transport in l...

OBJECTIVE Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly. Whether the atheroprotective biomechanical stimulus elicited by laminar shear stress modulates endothelial cell metabolism is not known. APPROACH AND RESULTS Here, we show that laminar flow exposure reduced glucose uptake and mitochondrial content in endothelium. Shear stress-mediated reduction...

Atherosclerotic lesions form preferentially in arterial regions characterized by slow and irregular patterns of blood flow such as those found on the inner curvature of bifurcation branch points. Because of this nonrandom distribution, extensive research has focused on the role of shear stress or the mechanical drag force exerted on the endothelial lining of blood vessels. Blood flow that follo...

Occurrence of laminar separation bubbles on solid walls of an elliptic cylinder has been simulated using a recently developed transitional model for boundary layer flows. Computational method is based on the solution of the Reynolds averaged Navier-Stokes (RANS) equations and the eddy-viscosity concept. Transitional model tries to simulate streamwise fluctuations, induced by freestream turbulen...

In the present paper mechanisms exploiting hydrodynamic instability of a laminar baseflow in order to control the size of a separation bubble are investigated in detail by means of 2D and 3D direct numerical simulations (DNS). An actuator introduces low amplitude TollmienSchlichting like boundary-layer disturbances into the flow upstream of the bubble, which become amplified and trigger early l...

This review is based on recently published data from our laboratory. We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet. Our findings suggest ...