In the present report, we describe a 3-year-old girl who presented with the full clinical and radiographic features of Larsen syndrome. The knee deformity in our patient was compatible with a complete (grade 3) anterior dislocation of the tibia on the femur. The reduction of knee dislocations in Larsen syndrome patients should be completed before treatment of the hips because 45 ̊ of knee flexio...

INTRODUCTION Cervical kyphosis may be potentially the most serious and, indeed, a life-threatening manifestation of Larsen syndrome because of the impingement on the spinal cord at the apex of the kyphosis. Abnormalities of the spine, specifically cervicothoracic kyphosis requires specific attention and management. CASE PRESENTATION We report on a 3-year-old boy who presented with full clinic...

Extreme learning machine (ELM) as a neural network algorithm has shown its good performance, such as fast speed, simple structure etc, but also, weak robustness is an unavoidable defect in original ELM for blended data. We present a new machine learning framework called “LARSEN-ELM” for overcoming this problem. In our paper, we would like to show two key steps in LARSEN-ELM. In the first step, ...

OBJECTIVES To evaluate patients with mutilans-like hand deformities in chronic inflammatory joint diseases and to determine radiographic scoring systems for arthritis mutilans (AM). METHODS A total of 52 patients with severe hand deformities were collected during 1997. A Larsen hand score of 0-110 was formed to describe destruction of the hand joints. Secondly, each ray of the hand was assess...

OBJECTIVE The TRAF1 genetic region conferring susceptibility to rheumatoid arthritis (RA) has been reported to associate with radiological damage. We aimed to test RA genetic susceptibility markers for association with a continuous measure of radiological damage over time using longitudinal modeling techniques. METHODS Sixty-seven RA susceptibility variants were genotyped in 474 patients in t...

OBJECTIVE To examine the influence of high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) on joint damage in patients with rheumatoid arthritis. METHODS Eight patients with active, refractory, progressively erosive RA were treated. The conditioning regimen consisted of intravenous administration of high doses of cyclophosphamide (totaling 200 mg/kg), with subsequent r...

We modelled the flow of the Larsen C and northernmost Larsen D ice shelves, Antarctic Peninsula, using a model of continuum mechanics of ice flow, and applied a fracture criterion to the simulated velocities to investigate the ice shelf’s present-day stability. Constraints come from satellite data and geophysical measurements from the 2008/09 austral summer. Ice-shelf thickness was derived from...

Our interest is in the cumulative probabilities Pr(L(t) ≤ l) for the maximum length of increasing subsequences in Poissonized ensembles of random permutations, random fixed point free involutions and reversed random fixed point free involutions. It is shown that these probabilities are equal to the hard edge gap probability for matrix ensembles with unitary, orthogonal and symplectic symmetry r...