INTRODUCTION Sorafenib and Sunitinib are the first tyrosine kinase inhibitors licensed for the treatment of advanced renal cell carcinoma. In contrast to conventional chemotherapy, targeted therapies have distinct and specific side effects. METHODS Selective review in Medline and the data base of the American Society of Clinical Oncology on the treatment and side effects of tyrosine kinase in...

From 23,231 total admission to three chil­dren's hospitals in Teheran over 3years and 6 months to 8 years period, 83 patients were found to have diabetes, 23 per thousand. The incidence of diabetes in children in­creases with age and is maximum in adoles­cence.  In 83 diabetic children 59 were male and 24 female (F /M:(0.4.)  From 83 diabetic patients 25 (31.2p.c.) were admitted with ketoacid...

Excessive weight gain occurred in a patient who was taking sodium valproate and phenytoin. The sodium valproate was therefore withdrawn but the rapid weight loss that ensued led to phenytoin intoxication. Hence a retrospective analysis was conducted of 100 children with epilepsy treated with sodium valproate. Fit control improved in 77 and was best in children with generalised epilepsy. None of...

almost as suddenly as it came in about two days, leaving behind no other symptom of cold except a slight congestion of the nasal mucous membrane. There is hardly any rise of temperature in most cases, a few varying between 99? to 100? F. at most. There is pronounced lassitude without marked headache or any congestion of the eyes, but some patients complain of aching of the whole body musculatur...

this is a letter to editor.there is growing interest in the health benefits of botanical diuretics. (1-2) ‎avicenna (980-1037 ad), the foremost iranian physician,‎‏ ‏introduced ‎numerous herbs as diuretics in his renowned book of canon of medicine. (3)‎avicenna and his followers have recommended herbal diuretics for most ‎ailments accompanied by fluid superabundance like lassitude, oedema, and ...

this is a letter to editor.There is growing interest in the health benefits of botanical diuretics. (1-2) ‎Avicenna (980-1037 AD), the foremost Iranian physician,‎‏ ‏introduced ‎numerous herbs as diuretics in his renowned book of Canon of Medicine. (3)‎Avicenna and his followers have recommended herbal diuretics for most ‎ailments accompanied by fluid superabundance like lassitude, oedema, and ...

The literature on emotional expression Social Network Sites (SNSs) is still in its infancy. It assumed that SNSs are subject to a positivity bias: individuals share positive aspects of their lives rather than negative ones. However, sentiment analysis studies have shown this bias might not be appropriate for all SNSs, particularly Twitter. This research aimed understand how the emotions message...

This article explores the representation of “plant horror” in fin de siècle “lost world” novels, from hideously dynamic carnivorous trees to mysterious plant-based drugs with power send their victims into torpid apathy. Such freakish flora can contribute new understandings imperial romance novel, specifically relation its depiction threatened masculinities. Combining modern ecocritical research...

intention to leave (itl) is defined as employee voluntary tendency to terminate employment in his/ him organization. indeed, this intention might not occur really, but its effects can be seen in forms of absence, lassitude, and sabotage. identifying antecedents or drivers, is one of the ways to prevent itl and its effects. present research results in 187 employees of payam-e-noor university sho...

In this issue of Journal, Yamamoto (1) reported the occurrence of latent primary adrenal insufficiency (PAI) in patients with low or low-normal early morning cortisol levels. It has previously been reported that the presence of gastrointestinal symptoms and anemia, especially in conjunction with autoimmune disorders, should alert the physician regarding the possibility of Addison’s disease (2)....