Neuropeptide Y (NPY) stimulates the release of GnRH in an estrogen (E2)-dependent manner, which is important in generating preovulatory GnRH surges. We tested the hypothesis that E2 up-regulates NPY's actions by stimulating NPY Y1 receptor (Y1r) gene expression through a mechanism mediated by E2's ability to induce progesterone (P) receptors (PRs). In initial experiments, a specific Y1r antagon...

The antero-ventral periventricular zone (AVPV) and medial preoptic area (MPOA) have been recognized as gonadal hormone receptive regions of the rodent brain that-via wiring to gonadotropin-releasing hormone (GnRH) neurons-contribute to orchestration of the preovulatory GnRH surge. We hypothesized that neural genes regulating the induction of GnRH surge show altered expression in proestrus. Ther...

Background: Adverse effects of high parathormone hormone (PTH) in critical illness have been described in some studies.  Objective: The relationship between high PTH levels with mortality in hospitalized patients with COVID-19 was evaluated in the present study. Methods: A total of 123 patients were included in the study. The patients were evaluated in phase 1 (on admission) and phase 2 (days...

Introduction: Ginger has shown anti-nociceptive effects. Here we investigated the possible involvement of GABAA receptors in anti-nociceptive effect of ginger using muscimol (GABAA agonist) and picrotoxin (GABAA antagonist) in rats that received ginger. The pain sensitivity was evaluated by formalin test. Methods: Thirty-five male Sprague-Dawley rats were randomly divided into 7 groups (n=5): s...

  In this study, the effects of lead acetate on two types of pain (nociception and inflammation) induced by formalin and its interaction with the opioid system and morphine-induced analgesia were examined. Male albino mice weighing 22-27 g were used in the experiments. Morphine was administered subcutaneously 30 minutes before formalin injection. Lead acetate was intraperitoneally administered ...

background and objectives: previous studies have shown the antinociceptive effect of morphine in animal models, but the specific anti-pain consequence of the abuse drug in female animals is unclear. the present research showed the morphine antinociception in female wistar rats using formalin test. materials and methods: subjects were 40 female wistar rats purchased from pasteur institute of ira...

Background and Objectives: Previous studies have shown the antinociceptive effect of morphine in animal models, but the specific anti-pain consequence of the abuse drug in female animals is unclear. The present research showed the morphine antinociception in female Wistar rats using formalin test. Materials and Methods: Subjects were 40 female Wistar rats purchased from Pasteur Institute of Ir...

introduction in spite of its short time period compared to the earth evolution history and formation, quaternary has had a significant effect on the final formation of the land form and vital resources. it is the final analysis of these levels and fully dependent sources to the earth genetic diseases and, above all, significant climate changes that have happened during this period; gavkhouni ba...

Abstract OBJECTIVE To compare progesterone (P4) concentrations measured with surface plasmon field-enhanced fluorescence spectroscopy (SPFS) and chemiluminescence immunoassay (CLIA) in serum plasma samples of client-owned bitches various ages breeds to determine reference ranges for P4 at stages the estrous cycle. SAMPLES 102 104 samples. PROCEDURES In experiment 1, 1 aliquot each was analyzed ...

background imaging plays a critical role not only in the detection, but also in the characterization of lung masses as benign or malignant. objectives to determine the diagnostic accuracy of dynamic magnetic resonance imaging (mri) in the differential diagnosis of benign and malignant lung masses. patients and methods ninety-four masses were included in this prospective study. five dynamic seri...