نتایج جستجو برای: latency associated transcript
تعداد نتایج: 1582937 فیلتر نتایج به سال:
Oncolytic virus (OV) is a kind of that can preferentially infect and kill tumor cells. The second oncolytic drug was herpes simplex (oHSV) Talimogene Laherparepvec (T-VEC). HSV-1 infectious cell culture protein 34.5 (ICP34.5) latency-associated transcript (LAT) genes are closely related to selective infection latent infection. Their engineering essential for constructing efficient safe oHSV. We...
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is abundantly expressed in latently infected sensory neurons. In small animal models of infection, expression of the first 1.5 kb of LAT coding sequences is necessary and sufficient for wild-type reactivation from latency. The ability of LAT to inhibit apoptosis is important for reactivation from latency. Within the fir...
From marker rescue, sequencing, transcript, and latency analyses of the thymidine kinase-negative herpes simplex virus mutant dlsactk and studies using the thymidine kinase inhibitor Ro 31-5140, we infer that the virus-encoded thymidine kinase is required in murine trigeminal ganglia for acute replication and lytic gene expression, for increasing the numbers of cells expressing latency-associat...
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