AIMS To prospectively evaluate the relationship between left atrial volume (LAV) and the risk of clinical events in patients with hypertrophic cardiomyopathy (HCM). METHODS We enrolled a total of 141 HCM patients with sinus rhythm and normal pump function, and 102 patients (73 men; mean age, 61±13 years) who met inclusion criteria were followed for 30.8±10.0 months. The patients were divided ...

Background Left atrial volume (LAV) is an important prognostic predictor in cardiac disease. LAV is not routinely evaluated by cardiac magnetic resonance (CMR) as acquisition of a full volume dataset is time consuming, and previous authors have shown calculation of LAV using the biplane area-length method (BAL) from routinely acquired 4 and 2 chamber views (4CV, 2CV) significantly underestimate...

BACKGROUND The risk factors for radiation pneumonitis (RP) in patients with chronic obstructive pulmonary disease (COPD) are unclear. Mean lung dose (MLD) and percentage of irradiated lung volume are common predictors of RP, but the most accurate dosimetric parameter has not been established. We hypothesized that the total lung volume irradiated without emphysema would influence the onset of RP...

The human immunodeficiency virus type 2 (HIV-2) strain LAV-2/B is able to infect a variety of human cell lines via a CD4-independent pathway. We have used the glycosylation inhibitors tunicamycin, swainsonine, and deoxymannojirimycin to further characterize this putative alternative receptor for HIV-2 (LAV-2/B). These antibiotics resulted in an increase (5- to 30-fold) in the susceptibility of ...

BACKGROUND The progression of chronic obstructive pulmonary disease (COPD) considerably varies among patients. Those with emphysema identified by quantitative computed tomography (CT) are associated with the rapid progression assessed by forced expiratory volume in one second (FEV1). However, whether the rate of the decline in lung function is independently affected by the regional distribution...

Post-operative atrial fibrillation (POAF) after valve surgery is associated with increased morbidity and mortality. Risk factors identified in the past to predict POAF are of moderate accuracy. We performed a retrospective analysis of 139 patients undergoing aortic valve replacement for aortic stenosis. Post-operative AF occurred in 44% of the patients. In multivariate analysis only left atrial...

Background and Aims: In the absence of mitral valve disease, increased left atrial volume (LAV) is a marker diastolic dysfunction longstanding elevated ventricle (LV) pressure. The aim this study was to assess role baseline LAV in predicting clinical outcome patients presenting with acute coronary syndrome (ACS).

This article advances our understanding of regression-based data mining by comparing the utility of Least Absolute Value (LAV) and Least Squares (LS) regression methods. Using demographic variables from U.S. state-wide data, we fit variable regression models to dependent variables of varying distributions using both LS and LAV. Forecasts generated from the resulting equations are used to compar...

Paraffin sections of retinal tissue from five patients who died from the acquired immune deficiency syndrome (AIDS) and retinopathy were examined by in situ hybridisation experiments with deoxyribonucleic acid (DNA) labelled with sulphur-35 of lentivirus, human T lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV), and cytomegalovirus. HTLV-III/LAV ribonucleic acid (RNA)...

We analyzed the prevalence of antibodies to HTLV-III/LAV in ex-residents from Angola and Mozambi que who returned to Portugal (Lisbon) before 1979. The absence of antibodies to HTLV-III/LAV suggests that the infection was not highly prevalent in these African countries before the development of the AIDS epidemic in the United States. Further studies of this type in ex-residents from other areas...