S-nitrosylation of proteins serves an important role in regulating diverse cellular processes including signal transduction, DNA repair, and neurotransmission. Identification of S-nitrosylation sites is crucial for understanding the significance of this post-translational modification (PTM) in modulating the function of a protein. However, it is challenging to identify S-nitrosylation sites dir...

The objective of this study was to evaluate the analytical performance of the Abbott ARCHITECT Tacrolimus immunoassay. Proficiency panels and specimens from a population of organ transplant recipients were analyzed in 6 clinical laboratories in Europe and the United States, and the results were compared with other methods. The ARCHITECT assay requires a whole blood specimen pretreatment step wi...

This study presents the immunomodulatory potential of Abrus precatorius Linn. (Indian wild licorice) leaves. A hydroalcoholic extract A. leaves (EAPL) was prepared by maceration. Thirty male mice were divided into five groups as follows: control group, model group (cyclophosphamide-treated), and three treatment (treated with EAPL at doses 100, 200 300 mg/kg, per os, daily for 14 days). Paramete...

Introduction The prostanoids are a family of biologically active lipids derived from the 20-carbon essential fatty acids (LCPUFA) which are involved in all aspects of the immune response including the resolution of inflammation. ω3-fatty acids, EPA DPA and DHA are anti-inflammatory, whilst the ω6fatty acid, Arachidonic acid (AA) and its metabolites: 13 (S)-HETE, TXB2, PGF2a and 6-k-PGF1a are pr...

Bu çalışma, süt ürünleri proses hatlarından izole edilen hem gram (-) de (+) biyofilm üreticisi bakterilerin QS sinyallerini göstermeyi amaçlamıştır. sinyallerinin profilini ve kimyasal bileşimini tanımlanması, mikrobiyal direnç gelişimi oluşumunun kontrolü için önemli bir faktördür. Özellikle izolatların olağan dışı davranışlarına odaklanılmıştır. İzolatların uzun zincirli AHL sinyalleri (C14-...

OBJECTIVE To investigate the antioxidant activities as well as phytochemical constituents of Antidesma thwaitesianum Müll. Arg. leaf extracts. METHODS The leaves of A. thwaitesianum were extracted using three different methods: blending with distilled water, maceration with ethanol and decoction. The chemical antioxidant activity of the plant leaf extracts was evaluated using 2,2-diphenyl-1-p...

Markov state models (MSMs) have become the tool of choice to analyze large amounts of molecular dynamics data by approximating them as a Markov jump process between suitably predefined states. Here we investigate "Core Set MSMs," a new type of MSMs that build on metastable core sets acting as milestones for tracing the rare event kinetics. We present a thorough analysis of Core Set MSMs based o...

Abstract Leaf compounds may contribute to plant defense against Cronartium rusts. Secondary are either natural or induced in leaves. We studied the variation of leaves six alternate hosts pini and two C. ribicola that represented susceptible resistant species these Extracts from were analyzed using LC-MSMS (liquid chromatography tandem mass spectrometry) compared between same genera identify si...