The catalytic mechanisms underlying Escherichia coli alkaline phosphatase's (AP) remarkable rate enhancement have been probed extensively. Past work indicated that whereas the serine nucleophile (Ser102) electrostatically repels the product phosphate, another oxyanion, tungstate, binds more strongly in the presence of Ser102. These results predict a covalent bond between the serine nucleophile ...

Lead Tungstate crystals will be used as calorimetric medium in high energy physics at CERN, in a particularly hostile radiation environment. Methods of testing their behaviour under irradiation are discussed here and are illustrated by some R&D results. Presented at 5th European Conference on Radiation and its Effects on Components and Systems, (Fontevraud, France, September 1999) For the CMS C...

An overview is given of the Lead Tungstate (PbWO4) electromagnetic crystal calorimeter for the CMS detector at the Large Hadron Collider (LHC) at CERN in Geneva. This includes a description of the engineering design, the development of the calorimeter components, the read-out system and results obtained in particle beams. Presented at IEEE Nuclear Science Symposium, Toronto, Canada, November 19...

This paper presents result of a study on undoped as well as various doped lead tungstate crystals. Radiation induced color center density was compared to radio luminescence. Light output degradation for crystals under irradiation was measured. Correlations between variations of crystal transmittance and light output were investigated. Monitoring wavelength was determined so that adequate sensit...

Abstract This paper presents result of a study on undoped as well as various doped lead tungstate crystals. Radiation induced color center density was compared to radio luminescence. Light output degradation for crystals under irradiation was measured. Correlations between variations of crystal transmittance and light output were investigated. Monitoring wavelength was determined so that adequa...

Nitrate reductase (NR) is an enzymatic source of nitric oxide (NO) in plants, and it needs Mo for the Mo-cofactor to be activated. Because NR-deficient mutants are not always available in some species, a cheap and simple pharmacological application of tungstate, which substitutes for Mo in the Mo-cofactor as a competitive antagonist, is widely used as a NR inhibitor in plant NO research. Howeve...