The observation that loss of orexin (hypocretin) neurons causes human narcolepsy raises the possibility that other acquired disorders might also result from loss of hypothalamic neurons. To test this possibility for body weight, mice with selective loss of melanin concentrating hormone (MCH) neurons were generated. MCH was chosen to test because induced mutations of the MCH gene in mice cause h...

raptor is a specific and essential component of mammalian TOR complex 1 (mTORC1), a key regulator of cell growth and metabolism. To investigate a role of adipose mTORC1 in regulation of adipose and whole-body metabolism, we generated mice with an adipose-specific knockout of raptor (raptor(ad-/-)). Compared to control littermates, raptor(ad-/-) mice had substantially less adipose tissue, were p...

Autophagy has been implicated in the ageing process, but whether autophagy activation extends lifespan in mammals is unknown. Here we show that ubiquitous overexpression of Atg5, a protein essential for autophagosome formation, extends median lifespan of mice by 17.2%. We demonstrate that moderate overexpression of Atg5 in mice enhances autophagy, and that Atg5 transgenic mice showed anti-agein...

BACKGROUND Squamous cell oesophageal cancer is one of the few neoplasms inversely related to body mass index (BMI). However, it is not clear whether this is due to cancer-related weight loss or to other correlates of leanness. PATIENTS AND METHODS 395 incident, histologically confirmed cases of squamous cell oesophageal cancer and 1,066 controls, admitted for acute, non-neoplastic diseases, i...

Amid rising market competitiveness, Industry Revolution (IR) 4.0 oriented technological integration is considered an imperative driver of sustainable organizational performances and green supply chain management. This study explores the role IR powered process technology innovation in enhancing Leanness, Green Supply Chain Management, Organizational Performance (including operational, economic,...

In the past several years, consumer demand has forced the swine industry to select for an animal with increased percent lean and higher lean accretion rates. Paylean is a technology that has been shown to increase carcass leanness while improving growth performance when fed to finishing pigs. It has been documented that average daily gain (ADG) and feed efficiency (F:G) are improved when feedin...

What is the role of IT capability in a competitive environment? Does IT capability contribute to the initiation of strategic actions within firms? To understand the relative position of IT in firms, we calculated the IT capability gap. This research has developed a research model in which the IT capability gap between two competing firms influences the leanness of a leading firm (Eroglu and Hof...