Treatment of Buruli ulcer, or Mycobacterium ulcerans disease, has shifted from surgical excision and skin grafting to antibiotic therapy usually with 8 weeks of daily rifampin (RIF) and streptomycin (STR). Although the results have been highly favorable, administration of STR requires intramuscular injection and carries the risk of side effects, such as hearing loss. Therefore, an all-oral, pot...

LAPACK and LINPACK both solve symmetric indeenite linear systems using the diagonal pivoting method with the partial pivoting strategy of Bunch and Kaufman (1977). No proof of the stability of this method has appeared in the literature. It is tempting to argue that the diagonal pivoting method is stable for a given pivoting strategy if the growth factor is small. We show that this argument is f...

Gaussian elimination is a canonical linear algebra procedure for solving linear systems of equations. In the last few years, the algorithm received a lot of attention in an attempt to improve its parallel performance. This article surveys recent developments in parallel implementations of the Gaussian elimination. Five different flavors are investigated. Three of them are based on different str...

This paper illustrates how the communication due to pivoting in the solution of symmetric indefinite linear systems can be reduced by considering innovative approaches that are different from pivoting strategies implemented in current linear algebra libraries. First a tiled algorithm where pivoting is performed within a tile is described and then an alternative to pivoting is proposed. The latt...

Rifampin (RIF) is a first-line drug used for the treatment of tuberculosis and other bacterial infections. Various RIF resistance mechanisms have been reported, and recently an RIF-inactivation enzyme, RIF phosphotransferase (RPH), was reported to phosphorylate RIF at its C21 hydroxyl at the cost of ATP. However, the underlying molecular mechanism remained unknown. Here, we solve the structures...

PURPOSE This article investigated the influence of novel rifampicin nanosuspension (RIF NS) for enhancing drug delivery properties. METHODS RIF NS was fabricated using the antisolvent precipitation technique. The impact of solvent type and flow rate, stabilizer type and concentration, and stirring time and apparatus together with the solvent-antisolvent volume ratio on its controlled nanocrys...

SILK is an expressive Semantic Web rule language and system equipped with scalable reactive higher-order defaults. We present two of its latest novel features. Omni rules are prioritized defeasible clauses that provide a higher-level expressive abstraction for users by making rules omni-directional. They handle multi-way conflicts. And they are soundly interoperable with FOL and W3C OWL as well...

We describe parallel implementations of LU factorization with pivoting for multicore architectures. Implementations that differ in two different dimensions are discussed: (1) using classical partial pivoting versus recently proposed incremental pivoting and (2) extracting parallelism only within the Basic Linear Algebra Subprograms versus building and scheduling a directed acyclic graph of task...

The aim of this study is to determine if the use of preimplantation genetic screening (PGS) by array comparative genomic hybridization (array CGH) and transfer of a single euploid blastocyst in patients with repeated implantation failure (RIF) can improve clinical results. Three patient groups are compared: 43 couples with RIF for whom embryos were selected by array CGH (group RIF-PGS), 33 coup...