Kitay A, Rybak L, Desai P, Villalobos CE, Wittig JC. Primary leiomyosarcoma of the proximal tibia: case report and review of the literature. Bull NYU Hosp Jt Dis. 2008;66(1):49-53. Leiomyosarcoma is a malignant entity that commonly affects the soft tissues of the body, such as the uterus, gastrointestinal system, and the soft tissues of the extremities. Primary leiomyosarcoma of the bone is a v...

PRUNE2 plays an important role in regulating tumor cell differentiation, proliferation, and invasiveness in neuroblastoma. Our previous study revealed that PRUNE2/OBSCN two-gene relative expression classifer accurately differentiated leiomyosarcoma from gastrointestinal stromal tumor. However, the association between PRUNE2 expression and prognosis in leiomyosarcoma is poorly understood. In thi...

PURPOSE Radiation therapy in low and high doses is known to be associated with the occurrence of late secondary sarcomas. The addition of chemotherapy has not been clearly demonstrated as a contributing factor. We describe three patients with radiation-associated leiomyosarcoma who had also received antimetabolite chemotherapy. METHODS Three cases of leiomyosarcoma occurring 9-27 years after ...

INTRODUCTION Leiomyosarcomas are neoplasms of smooth muscles that most commonly arise from the uterus, gastrointestinal tract, or soft tissue. Primary pleural leiomyosarcoma is extremely rare. To the best of our knowledge, only nine cases have been published to date. Because of the rarity of pleural leiomyosarcoma and its similarity (clinical and histological) to other pleural neoplasms, partic...

Primary hepatic leiomyosarcoma is very rare and no primary myxoid leiomyosarcoma in the liver has been reported yet. Most cystic space-occupying lesions in the liver are benign in nature. But, rarely, malignancy could appear as a cystic lesion by ultrasonographic examination. A 64-year-old woman with a huge cystic mass detected by hepatic ultrasonography was diagnosed as primary hepatic myxoid ...

This paper discusses liver resection for intraabdominal leiomyosarcoma metastases as a therapy for carefully selected patients. Of the 83 hepatectomies performed from 1992 to 1996, five were resections for liver metastases due to intraabdominal leiomyosarcoma, in 3 patients. The surgical indication was single liver metastases, without any evidence of extrahepatic disease. No mortality occurred ...

Scrotal leiomyosarcoma is a rare tumor arising from the dartos layer of the scrotum presenting as firm, rubbery, non-tender, irregular mass. To date about 37 cases of leiomyosarcoma of scrotum have so far been reported. Treatment involves wide surgical excision with tumor free margins. We report a case of scrotal leiomyosarcoma in a 48-year-old man which was treated by a wide surgical excision ...

Primary leiomyosarcoma of the breast is a rare tumour with only around thirty cases reported in the literature. Most of the cases reported are in females, while only a few are reported in males. We present a case of primary breast leiomyosarcoma in a 59-year-old man that presented with a subareolar lump which felt to be benign clinically and radiologically but proven to be a leiomyosarcoma on e...

Primary pancreatic leiomyosarcoma belongs to a rare group of malignant soft tissue tumors. we present clinical case 61-year-old patient who underwent hemipancreatectomy with splenectomy for tumor in 2018. Histological and immunohistochemical studies confirmed the diagnosis leiomyosarcoma. three years, has been observed at N.N. Blokhin National Medical Research Center Oncology ministry Health Ru...

To identify potential oncogenes that contribute to the development of uterine leiomyosarcoma, we conducted a cDNA microarray analysis between normal uterine smooth muscle and uterine leiomyosarcoma. We found that acrogranin (also named PCDGF or progranulin) is overexpressed in uterine leiomyosarcoma. With immunohistochemical staining of 12 leiomyosarcoma cases, we verified acrogranin expression...