AIM To assess lens thickness measurements with anterior segment-optical coherence tomography (AS-OCT) in comparison with A-scan ultrasonography (A-scan US). METHODS There were 218 adult subjects (218 eyes) aged 59.2±9.2y enrolled in this prospective cross-sectional study. Forty-three eyes had open angles and 175 eyes had narrow angles. Routine ophthalmic exam was performed and nuclear opacity...

PURPOSE The goal of this study was to determine the role of Src family kinases (SFKs) in the development of lens cataract. This question was particularly significant, because these tyrosine kinases mediate the stress pathways known to lead to cataract formation. The experiments were focused on whether the inhibition of SFK activity suppresses the formation of lens opacities. METHODS A whole-l...

A Cataract, is an opacity within a lens. Out of various eye disorders CATARACT “Clouding of eye lens” is a major problem encountered in canines, and ophthalmic surgery offers great potential for relief of distress and improvement of quality of life. Like a camera eyes have a clear lens inside them that is used for focusing the light. Surgical removal of cataract is a treatment of choice, if res...

BACKGROUND Intranasal corticosteroids (INCS) are prescribed for the long-term prophylactic treatment of inflammatory upper airway conditions. Although some systemic absorption can occur via topical routes, the clinical relevance is controversial. The effects of orally administered corticosteroids on intraocular pressure (IOP) and lens opacity (LO) are well established, but the impact of the INC...

This study developed a computational model to assess the optical properties of nuclear cataracts, using slit-lamp lens images for clinical evaluation based on color and opacity. Cataracts were represented as spherical particles distinct from surrounding medium, with diameters ranging tens hundreds nanometers. examined effects particle diameter, concentration, colorimetric opacity cataracts thei...

AIMS To assess the reproducibility and validity of a new instrument for grading nuclear cataract-the laser slit lamp, by comparison with an established method of lens grading-the Lens Opacities Classification System III (LOCS III). METHODS 62 volunteers (113 eyes) were examined on two occasions. At each visit, a video image of the anterior segment was captured with the laser slit lamp and sto...

BACKGROUND/AIMS The National Institute for Health and Care Excellence (NICE) has recommended the use of ranibizumab for neovascular age-related macular degeneration (AMD) and for diabetic macular oedema (DMO) as part of its health technology appraisal process. In the economic evaluations of both interventions, utility values were derived from members of the general public wearing contact lenses...

Glutaredoxin 2 (Grx2) is an isozyme of glutaredoxin1 (thioltransferase) present in the mitochondria and nucleus with disulfide reductase and peroxidase activities, and it controls thiol/disulfide balance in cells. In this study, we investigated whether Grx2 gene deletion could induce faster age-related cataract formation and elucidated the biochemical changes effected by Grx2 gene deletion that...

Diabetic cataract is an ocular disease represented as blindness by lens opacification. Oxidative as well as osmotic stress caused by accumulation of polyols within the lens has been shown to be associated with glucose-induced cataractogenesis. Taurine has an antioxidant capacity and its level in diabetic cataractous lens is markedly decreased. Therefore, we investigated whether taurine is a par...

PURPOSE Oxidative stress in the human lens leads to a wide range of damage including DNA strand breaks, which are likely to contribute to cataract formation. The protein Ku80 is a fundamental component of the nonhomologous end-joining pathway that repairs DNA double strand breaks. This study investigates the putative impact of Ku80 in cataract prevention in the human lens. METHODS The present...