Leonotisleonurus a shrub indigenous to Southern Africa is widely used in traditional medicine to treat a variety of conditions ranging from skin diseases and cough to epileptic fits and ‘heart problems’. Studies on the aqueous extract of the leaves have indicated cycloxegenase enzyme inhibitory activity and an antihypertensive effect. Five methanol leaf extract fractions (MLEa MLEe) of L. leonu...

Objective: To substantiate the possibility of using polarimetry to control quality tinctures as an additional pharmacopoeial method. Methods: The polarimetric method (POL-1/2, Atago, Japan, measurement accuracy of±0.002 °) was used measure optical activity (α motherwort, valerian and hawthorn tinctures. dynamic light scattering (DLS; Zetasizer Nano ZS, Malvern, UK) assess stability alcoholic aq...

Introduction . Natural deep eutectic solvents (DESs) are promising extractants for many biologically active substances from plant raw materials. They biodegradable, safe, stable, their production is affordable and easily feasible, the extraction efficiency comparable to known organic solvents. In this regard, interest in has been steadily growing recent years, they being used various fields of ...

In response to crowding, locusts develop characteristic black patterns that are well discernible in the gregarious phase at outbreaks. We report here a dark-color-inducing neuropeptide (dark-pigmentotropin) from the corpora cardiaca of two plague locusts, Schistocerca gregaria and Locusta migratoria. The chromatographic isolation of this neuropeptide was monitored by using a bioassay with an al...

The corpora cardiaca of the cockroach Nauphoeta cinerea contain a hypertrehalosaemic hormone (HTH) which is chemically characterized as a blocked decapeptide. The synthetic HTH shows the same chromatographic behaviour as the material isolated from corpora cardiaca. The synthetic peptide causes hypertrehalosaemia and fat body glycogen phosphorylase-activation in N. cinerea as well as in the Amer...

A new 15,16-dinorlabdane diterpenoid 1 and a known labdane diterpenoid 2, together with three known ergosterols 3-5, were isolated from the EtOAc-soluble portion of the EtOH extract of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. Compound 1 showed in vitro coagulant activity in the APTT, PT, TT, and FIB assays.

Five new syringyl acylated flavonol glycosides, named leonurusoides A (1), B (2), C (3), D (4), and E (5), together with one known one 6 were obtained from the aerial parts of Leonurus japonicus. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI-TOF-MS, 1D and 2D NMR). Compounds 1-6 showed triglyceride (TG) accumulation inhibitory effects in free fatty acid-i...

The use the aqueous decoction of Leonotis leonurus (L. leonurus) (Ll) R. Br. (Lamiaceae) in the treatment of hypertension (HPT) in traditional medicine is well documented. The effect of the aqueous extract of LI on the blood pressure (BP) and heart rate (HR) has been investigated in normotensive rats. The aim of this study was to investigate the effect of Ll aqueous extract on the in isolated p...