Abstract The sign of Leser–Trélat is a paraneoplastic phenomenon consisting sudden eruption seborrhoeic keratoses. It credited to two surgeons, Edmund Leser (1853–1918) and Ulysse Trélat (1827–1890), who described cutaneous lesions associated with internal malignancies. Leser, the author Textbook Special Surgery in 50 Lectures, initially studied law Bonn before qualifying medicine Leipzig 1880....

We report the case of a 79-year-old Caucasian man, who developed numerous pruritic seborrheic keratoses on his chest and back within one year. An underlying malignant disease was suspected. Upper and lower endoscopies were performed and the patient was diagnosed with adenocarcinoma of the ascending colon. We discuss the clinical significance of his cutaneous symptoms/signs, and review the medic...