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Potential acetylcholine receptor (AChR) mutants of the nematode are selectable by resistance to the neurotoxic drug levamisole, a probable cholinergic agonist. To determine which mutants may have achieved resistance through loss of levamisole receptor function, we have assayed mutant extracts for specific 3H-meta-aminolevamisole binding activity in the presence and absence of mecamylamine. We f...

Levamisole is an anthelminthic drug that usually used as a cutting agent to lace illicit cocaine samples and has been classified dangerous substance. In this work, we report on the fabrication of novel fluorescence sensor for levamisole using AuZnFeSeS alloyed quantum dots (QDs)-molecularly imprinted polymer (MIP) nanocomposite. Firstly, organic-phased QDs were synthesized via organometallic ho...

Levamisole is a known contaminant of cocaine and, via this route, has been associated with otherwise unexplained agranulocytosis. Levamisole is currently present in the majority of cocaine samples seized by the US Drug Enforcement Agency. We identified 20 cases of unexplained agranulocytosis in our practice locations of Albuquerque, NM, and Vancouver, Canada. Epidemiologic investigation reveale...

The specific and non-specific immune response and immunomodulatory effect of levamisole were studied in dogs with altered immune function due to giardiosis and vaccinated against canine parvovirus (CPV) infection. In immunosuppressed dogs combination of vaccine with levamisole treatment enhanced depressed phagocytic ability and stimulated proliferation activity of lymphocytes. CPV antibody prod...

BACKGROUND AND AIM: The aim of this study was to systematically analyze the effect of levamisole on treatment of recurrent aphthous stomatitis (RAS).METHODS: An electronic search was executed in PubMed, Cochrane, and Scopus after determining the research question using the appropriate Medical Subject Heading (MeSH) term covering the period from 1975 to 2015. Additional publications from hand se...

PATIENT Male, 36 FINAL DIAGNOSIS: Levamisole-induced vasculopathy Symptoms: Purpuric skin lesions Medication: Levamisole Clinical Procedure: - Specialty: Internal Medicine. OBJECTIVE Unusual clinical course. BACKGROUND Levamisole has been detected in seized cocaine samples and a levamisole-induced vasculopathy (LIV) has been described, mainly focused on skin. CASE REPORT A 36-year-old Cau...

Levamisole is an anthelmintic agent that exerts its therapeutic effect by acting as a full agonist of the nicotinic receptor (AChR) of nematode muscle. Its action at the mammalian muscle AChR has not been elucidated to date despite its wide use as an anthelmintic in humans and cattle. By single channel and macroscopic current recordings, we investigated the interaction of levamisole with the ma...