the present study was designed to assess the efficacy of fentanyl and pancuronium combined with dilute lidocaine solution for axillary block. onehundred adult patients undergoing upper limb surgery were randomly allocated to receive either 0.6 ml/kg of 1 % lidocaine (6 mg/kg) or 0.6 mllkg of 0.5% lidocaine (3 mg/kg) with 1 µg/kg of fentanyl and 0.5 mg of pancuronium. the onset of sensory and mo...

BACKGROUND Intraoperative lidocaine is widely used in controlling discomfort during cataract surgery. However, recent studies have confirmed the toxic effect of lidocaine on ganglion cells. Ropivacaine is an anesthetic recently introduced in clinical practice that couples a long anesthetic effect with a mild vasoconstrictive action. OBJECTIVE The aim of this study was an in vitro evaluation o...

Bupivacaine is a widely used long-acting local anaesthetic. In clinical practice, a mixture of bupivacaine and lidocaine is often used in order to combine the faster onset of sensory blockade of lidocaine with more profound and longer duration of blockade by bupivacaine. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocai...

Primary ventricular fibrillation (VF) during an acute myocardial infarction (AMI) occurs with a high incidence and mortality rate with or without thrombolysis. The incidence varies from 2% to 19% depending on the definition of "primary." Primary VF in this study refers to fibrillation occurring in the absence of shock or pulmonary edema. Mortality rate, when primary VF occurs, is 2 to 4 times g...

We read the article by Bapat et al., 1 with interest. They demonstrated the good quality of laryngeal mask (LMA) insertion with midazolam-thiopentone and the poor conditions with lidocainethiopentone. We would like to bring to your attention two studies we published earlier this year. In the first 2 we showed that topical 40 mg lidocaine followed by 5 mg-kg -1 thiopentone produced conditions fo...

The currently available local anesthetic agents are capable of providing high quality nerve blockade in a wide variety of clinical circumstances. Our understanding of the mechanisms and consequences of toxicity is increasing rapidly. Knowledge of the chemistry of local anesthetics has enabled clinicians to exploit the increased safety. Local anesthesia is an important part of the daily routines...

The present study was designed to assess the efficacy of fentanyl and pancuronium combined with dilute lidocaine solution for axillary block. Onehundred adult patients undergoing upper limb surgery were randomly allocated to receive either 0.6 mL/kg of 1 % lidocaine (6 mg/kg) or 0.6 mLlkg of 0.5% lidocaine (3 mg/kg) with 1 µg/kg of fentanyl and 0.5 mg of pancuronium. The onset of sensory a...

Intravenous lidocaine has the potential to control seizures. This article reviews the available evidence related to lidocaine's efficacy and clarifies its potential role in the management of status epilepticus (SE). Although there are no large, double-blind, placebo-controlled studies of lidocaine's efficacy in SE, numerous case reports and case series support its use. Most of the reported case...

This text presents complementary data corresponding to pharmacological and toxicological characterization of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide (LIA) compound. These data support our research article entitled "Pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analog of lidocaine" Déciga-Campos M., Navarrete-Vázquez G., López-M...