KRas is a major proto-oncogene product whose signaling activity depends on its level of enrichment on the plasma membrane (PM). This PM localization relies on posttranslational prenylation for membrane affinity, while PM specificity has been attributed to electrostatic interactions between negatively charged phospholipids in the PM and basic amino-acids in the C terminus of KRas. By measuring k...

Laboratory experiments conducted on the multichambered planktic foraminifera Globigerinoides sacculifer are used to determine the effect of symbiont photosynthesis on shell carbon and oxygen isotopic composition. Stable isotope analyses of individual chambers secreted under controlled temperature and light levels show that chamber jl3C values increase with increasing light levels. The effect of...

The spermatogonial stem cell initiates and maintains spermatogenesis in the testis. To perform this role, the stem cell must self replicate as well as produce daughter cells that can expand and differentiate to form spermatozoa. Despite the central importance of the spermatogonial stem cell to male reproduction, little is known about its morphological or biochemical characteristics. This result...

keybarkuh area is located 70 km southwest of khaf, khorasan razavi province. the study area is situated in northeastern lut block. the rock units in the area are paleozoic metamorphic rocks and cretaceous to tertiary subvolcanic intrusions intruded as dike, stock and batholith; their composition varies from granite to diorite. based on magnetic susceptibility, the intrusive rocks are divided in...

The oxygen isotope composition in leaf water and organic compounds in different plant tissues is useful for assessing the physiological performance of plants in their environment, but more information is needed on Delta(18)O variation during a diel course. Here, we assessed Delta(18)O of the organic matter in leaves, phloem and xylem in stem segments, and fine roots of Ricinus communis during a...

Most HWRs currently use natural uranium fuel. Using enriched uranium fuel results in a significant improvement in fuel cycle costs and uranium utilization. On the other hand, reactivity changes of HWRs over the full range of operating conditions from cold shutdown to full power are small. This reduces the required reactivity worth of control devices and minimizes local flux distribution perturb...

Chromatin immunoprecipitation (ChIP) is the gold-standard technique for localizing nuclear proteins in the genome. We used ChIP, in combination with deep sequencing (Seq), to study the genome-wide distribution of the Silent information regulator (Sir) complex in Saccharomyces cerevisiae. We analyzed ChIP-Seq peaks of the Sir2, Sir3, and Sir4 silencing proteins and discovered 238 unexpected euch...

Several mycobacteriophages active against mycobacteria have been isolated by Takeya and Yoshimura (1957) using the soil-enrichment technique. Among these phages, B-1 was found to have the broadest host range including virulent strains of tubercle bacilli. In the present investigation the interactions between mycobacteriophage B-1 and its host strain Mycobacterium avium were examined under the l...

A genomic reconstruction belonging to the genus Methanosarcina was assembled from metagenomic data from a methane-producing enrichment of Antarctic permafrost. This is the first methanogen genome reported from permafrost of the Dry Valleys and can help shed light on future climate-affected methane dynamics.