the insulin-like growth factor i receptor (igf-ir) plays an essential role in the establishment and maintenance of transformed phenotype. interference with the igf-ir pathway by antisense causes reversal of the transformed phenotype in many rodent and human tumor cell lines. we stably transfected the pc-3 human prostate cancer cell line with an igf-ir antisense rna expression plasmid. the numbe...

background: the pathogenesis of inflammatory bowel disease is complex and multifactorial. studies have led to the current concept that toll-like receptors represent key mediators of innate host defense in the intestine, and they are involved in maintaining mucosal as well as commensal homeostasis. we studied the possibility of simvastatin and antagonist of receptors of interleukin-1 for pharmac...

Abstract The innate immune system is equipped with multiple receptors to detect microbial nucleic acids and induce type I interferon (IFN) restrict viral replication. When dysregulated these receptor pathways inflammation in response host promote development persistence of autoimmune diseases like Systemic Lupus Erythematosus (SLE). IFN production regulated by the Interferon Regulatory Factor (...