The etiology of NIDDM is complex and development is manifested by initial insulin resistance coupled with elevated insulin levels in the early diabetic state with concomitant increases in circulating levels of glucose and triglycerides. This is followed by a decline in insulin levels due to pancreatic exhaustion. Our results show that administration of DHEA-PC, a conjugate of dehydroepiandroste...

Objectives The aim of this study was to determine the effects of fenofibrate (160 mg/d) on fasting and postprandial lipoproteins, oxidized fatty acids, and inflammatory mediators in subjects with hypertriglyceridemia and the metabolic syndrome. Research Design and Methods Fifty-nine subjects with fasting hypertriglyceridemia (≥1.7 mmol/L and <6.9 mmol/L) and two or more of the Adult Treatment P...

Introduction: Islet transplantation has become a promising treatment for type I diabetes mellitus due to recent success since the development of the Edmonton Protocol. Islet culture prior to transplantation is standard practice in several clinical islet programs. High-density islet culture is desirable because it reduces space and handling requirements during culture, but it exacerbates oxygen ...

Nicotine elicited membrane depolarization, elevation of intracellular calcium, rubidium efflux, and release of insulin from mouse -TC6 insulinoma cells. Such responses were blocked by the nicotinic antagonist mecamylamine but not by the muscarinic antagonist atropine. Neither the selective 4 2 antagonist dihydro-erythroidine nor the selective 7 antagonist methyllycaconitine significantly blocke...

Macrolide antibiotics possess immunomodulatory/anti-inflammatory properties. These properties are considered fundamental for the efficacy of macrolide antibiotics in the treatment of chronic inflammatory diseases like diffuse panbronchiolitis and cystic fibrosis. However, the molecular mechanisms and cellular targets of anti-inflammatory/immunomodulatory macrolide activity are still not fully u...

Organophosphorus nerve agent (OP) poisoning induces death through different mechanisms including respiratory and cardiovascular major dysfunctions. Epileptic seizures, status epilepticus and seizurerelated brain damage (SRBD) complicate the clinical picture. Recently different publications showed that neuro-inflammatory events take place during OP-induced seizures but their role in SRBD and pos...

24 The factors that influence the timing of puberty and the onset of adult fertility are poorly 25 understood. While focus on the juvenile period has provided insights into how growth-related 26 cues affect pubertal timing, growth velocity during infancy that is sustained into the juvenile 27 period may be important. On the other hand, social factors, specifically exposure to 28 psychosocial st...