Background: Fumaric acid esters (FAE) have been used as a drug since 1959. The therapeutic preparation containing FAE has been one of the prominent drugs used for the systemic treatment of psoriasis since 1994 in Germany. FAE have been used in the treatment of sarcoidosis, granuloma annulare, necrobiosis lipoidica, cheilitis granulomatosa, annular elastotic giant cell granuloma, malignant melan...

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterised by small papules that evolve into annular/polycyclic plaques. Plaques typically have a slightly raised border; the centre may be hypopigmented and/or atrophic. Lesions are usually located on sun-exposed areas such as the face and the neck (1, 2). Histologically, AEGCG is associated with multinucl...

INTRODUCTION Authors describe human schistosomal granuloma in late chronic phase, from the morphological and evolutionary viewpoints. METHODS The study was based on a histological analysis of two fragments obtained from a surgical biopsy of peritoneum and large intestine of a 42-year-old patient, with a pseudotumoral form mimicking a peritoneal carcinomatosis associated to the schistosomiasis...

Sir, Annular elastolytic giant cell granuloma (AEGCG) is a rare skin disease. It is characterized clinically by annular lesions and histopathologically by giant cell elastophagocytosis on the active border of the lesion and a loss of elastic fibres in the centre in non-sun-damaged skin. The pathogenesis remains controversial. We report the case of a 32-year-old man with a unique, long-course le...

Naked sarcoidal granulomas are supposedly characteristic, but not pathognomonic of sarcoidosis. Other types of histopathological pattern can also happen in sarcoidosis and may lead to misdiagnosis. Thirteen archival skin specimens taken from 10 patients were retrieved from our fi le for study. All patients were labeled as sacroidosis based on histological evidence of noncaseating granuloma foun...