results no borrelia dna was detected by pcr in skin lesions of patients with morphea. patients and methods sixty six patients with morphea were prospectively included in the present study. for each patient, formalin-fixed, paraffin-embedded tissue blocks of skin lesion biopsies were examined for borrelia spp. dna using pcr. objectives we aimed to find the frequency of borrelia in morphea lesion...

Morphea is a connective tissue disorder characterized by skin homogenization. No protocol of therapy is agreed upon, due to the variation in disease presentations as well as follows up methods. UVA-1 is an effective therapy due to deep penetration of the skin. The aim of the study was to evaluate the efficacy, safety and side effects of medium dose (30 J/cm ) UVA-1 phototherapy for the treatmen...

BACKGROUND Localized scleroderma (LSc) is characterized by cutaneous fibrosis and various autoantibodies. OBJECTIVE To determine the presence or levels of antibodies (Abs) against matrix metalloproteinase (MMP)-1 and their clinical relevance in LSc. METHODS Anti-MMP-1 Ab was examined by ELISA (Enzyme-Linked ImmunoSorbent Assay) and immunoblotting using human recombinant MMP-1. MMP-1 collage...

how to cite this article: allmendinger am, ricci ja, desai ns, viswanadhan n, rodriguez d. atypical neuroimaging manifestations of linear scleroderma “en coup de sabre”. iran j child neurol. summer 2015;9(3):62-68. abstract linear scleroderma “en coup de sabre” is a subset of localized scleroderma with band-like sclerotic lesions typically involving the fronto-parietal regions of the scalp. pat...

Localized scleroderma (morphea) usually develops spontaneously, but the precise mechanisms underlying disease development are obscure. However, a significant number of cases suggest that morphea is induced by external stimuli. Herein, we report a case of morphea that developed after a needle biopsy.

Background and aim A possible aetiological connection between skin sclerosis and infection with Borrelia burgdorferi (Bb) has been discussed. Studies investigating the link between Bb and morphea have produced conflicting results. In several series, all patients with morphea tested have been seronegative. Other studies have found specific antibodies to Bb in between 6% and 54% of patients with ...

Morphea is an uncommon, indolent, dermatologic disorder characterized by dermal fibrosis and collagen deposition. Its appearance during pregnancy is rare. We report a case of 34-yearold woman, 3 months pregnant, presented with a two-month history of localized skin changes on the left breast. The lesion gradually increased in size. On examination, we noticed an atrophic and retracted left breast...

BACKGROUND Morphea is an inflammatory autoimmune skin sclerosis of unknown etiology. A causative role of Borrelia burgdorferi infection has been controversially discussed, but no conclusive solution has yet been achieved. OBJECTIVE Intrigued by 3 young patients with severe Borrelia-associated morphea and high-titer antinuclear antibodies, we retrospectively examined the relationship between B...