This paper presents a methodology for the analysis of the linkage among the processes in an organization. The methodology has three main steps: model construction; connectivity analysis; and structure analysis. The model construction step generates a linkage matrix which is used in the following steps. The connectivity analysis is based on linkage consistency and interprocess coupling metrics, ...

Linkage analysis of neurofibromatosis was performed using genes on chromosomes 1, 8, 11, and 12. No linkage was found between NF and C-myc, AT 3, IGF-1, PTH, and gamma globin genes. Evidence for linkage was found between C-ets 1, on the long arm of chromosome 11 and NF in two families with a lod score of 1.88 at theta = 0. More families are being studied to confirm this linkage.

Bioinformatics is a discipline at the intersection of biology, computer science, information technology andmathematics. It aims at integrating and analysing awealth of biological data with the aim of identifying and assigning a function to each of the parts list of a living organism and understanding the incredibly complex processes that define life at a systems level. It is applied, for exampl...