2΄-5΄-linked RNAs play important roles in many biological systems. In addition, the mixture of 2΄-5΄ and 3΄-5΄ phosphodiester bonds have emerged as a plausible structural element in prebiotic RNAs. Toward our mechanistic studies of RNA folding and structures with heterogeneous backbones, we recently reported two crystal structures of a decamer RNA duplex containing two and six 2΄-5΄-linkages, s...

Cam-modulated linkages that can achieve superior kinematic performance as compared with pure linkages have been widely applied in a variety of automation machinery. The tolerance analysis and synthesis are thus quite essential in the design and manufacture of precision cam-modulated linkages. This paper presents comprehensive and systematic mathematical tools for dealingwith the tolerance analy...

in the light of the 2008 world development report, this paper revisits the impact of agriculture on overall economic growth, in the case of an oil producing country, using indices of intersectoral linkages. to this end, four input-output tables of iran’s economy are utilized. the results support the importance of the agricultural sector in stimulating the economic growth of iran, but also s...

A graph is k-linked if any k disjoint vertex-pairs can be joined by k disjoint paths. We improve a lower bound on the linkedness of polytopes slightly, which results in exact values for the minimal linkedness of 7-, 10and 13-dimensional polytopes. We analyze in detail linkedness of polytopes on at most (6d + 7)/5 vertices. In that case, a sharp lower bound on minimal linkedness is derived, and ...

Betti numbers of configuration spaces of mechanical linkages (known also as polygon spaces) depend on a large number of parameters – the lengths of the bars of the linkage. Motivated by applications in topological robotics, statistical shape theory and molecular biology, we view these lengths as random variables and study asymptotic values of the average Betti numbers as the number of links n t...

This paper takes an economic approach to investigate the role of geographical proximity for organizing new product development (NPD) activities within inter-firm linkages. Product development theory and the resource-based view is discussed from an inter-firm perspective and contrasted to arguments in the literature on geographical economics. The approach in this paper assumes that geographical ...

The use of biodiversity surrogates has been discussed in the context of designing habitat linkages to support the migration of species affected by climate change. Topography has been proposed as a useful surrogate in the coarse-filter approach, as the hydrological process caused by topography such as erosion and accumulation is the basis of ecological processes. However, some studies that have ...

In the globalization context and competitiveness, the role of a university is further enhanced. University is no longer confined to traditional roles. Universities need to interact with others in order to be relevant and progressive. Symbiosis relationships between the university and industry are very significant because the relationship between those two can foster economic development of a na...

This paper studies the configuration space of all possible positions of a linkage in R n. For example, it shows that for every compact algebraic set, there is a linkage whose configuration space is analytically isomorphic to a finite number of copies of the algebraic set. If flexible edges are allowed, any compact set given by polynomial equalities and inequalities is the configuration space of...