PURPOSE To compare 1-year transepithelial corneal collagen cross-linking with iontophoresis (I-CXL) outcomes with standard CXL (S-CXL) epithelium-off for progressive keratoconus. METHODS Forty eyes of 40 patients with progressive keratoconus were included in this comparative, prospective clinical study. Corrected distance visual acuity (CDVA), spherical equivalent, cylinder refraction, cornea...

Corneal cross-linking (CXL) is an option that in the last decade has demonstrated its efficacy and safety in halting the progression of keratoconus (KCN) and other corneal ectasias. Its indication has been extended beyond the classic definition that required evidence of KCN progression, especially in the presence of some risk factors for a possible progression (particularly the younger age). Ho...

PURPOSE To compare the effect of corneal cross-linking (CXL) for keratoconus in various age groups and to investigate the influence of the topographic cone location on the outcome of CXL. METHODS This cohort study included 95 patients (119 eyes) diagnosed as having progressive keratoconus who underwent epithelium-off standard protocol CXL from January 2010 through May 2012. For statistical an...

We read with interest the editorial entitled “Corneal Cross-linking (CXL): Standardizing Terminology and Protocol Nomenclature.”1 We would like to clarify that we recommended the use of the term “corneal crosslinking” in a previous publication.2 For the sake of completeness, a comprehensive bibliography supporting this claim is added here for the journal’s readers.3-6 In the same editorial, we ...

PURPOSE To compare the corneal collagen cross-linking (CXL) demarcation line depth between the central and peripheral cornea after cross-linking using anterior segment optical coherence tomography. METHODS Retrospective interventional case series of 38 eyes with keratoconus or postoperative LASIK ectasia treated with riboflavin ultraviolet A CXL (UV-X, IROC). CXL demarcation line depth, corne...

PURPOSE We compared the efficacy and early morphological changes in the cornea following conventional (C-CXL), transepithelial by iontophoresis (I-CXL), and accelerated (A-CXL) collagen cross-linking in keratoconus. METHODS A total of 45 eyes of 45 patients with progressive keratoconus who underwent corneal collagen crosslinking (CXL) was divided into three groups: C-CXL (n = 15), A-CXL (n = ...

background: corneal collagen cross-linking with riboflavin, also known as collagen cross-linking (cxl), involves the application of riboflavin solution to the eye that is activated by illumination with ultraviolet a (uva) light. we survey here the topographic corneal changes one year after cxl in patients with corneal keratoconus. materials and methods: this prospective randomized clinical tria...

PURPOSE To establish corneal cross-linking (CXL) with riboflavin and UV-A in in the mouse cornea in vivo and to develop tools to measure the biomechanical changes observed. METHODS A total of 55 male C57BL/6 wild-type mice (aged 5 weeks) were divided into 14 groups. Standard CXL parameters were adapted to the anatomy of the mouse cornea, and riboflavin concentration (0.1%-0.5%) and fluence se...

PURPOSE To evaluate the changes in corneal transparency and thickness measured objectively using Pentacam Scheimpflug (Oculus Optikgeräte GmbH) corneal tomography (densitometry) after corneal cross-linking (CXL). METHODS Twenty-two eyes from 15 patients with keratoconus underwent CXL. Corneal thickness and curvature as well as lens and corneal densitometry were measured at baseline and 1, 3, ...