three fatty acid desaturase gene FAD3 (Bilyeu et al., 2003). GmFAD3A was also characterized as the most One major locus (Fan) and several minor loci have been shown highly expressed of the three homologs in developing to contribute to the linolenic acid level in soybean [Glycine max (L.) Merr.] seeds. The Fan gene encodes a microsomal omega-3 fatty acid seeds. The relative importance of GmFAD3B...

The desaturation-elongation of [14C]linolenic acid (n-3) in the rat small intestine was examined in homogenates of villus and crypt cells in vitro and in mesenteric lymph duct cannulated rats in vivo, using high performance liquid chromatography of fatty acid methyl esters with continuous flow measurement of 14C. Desaturation-elongation of [14C]18:3 to [14C]18:4, [14C]20:4, and [14C]20:5 (n-3) ...

The serum concentration of lipids and composition of fatty acids after overnight fasting were studied in 18 patients with rheumatoid arthritis treated for 12 weeks with either 20 ml of evening primrose oil containing 9% of gamma-linolenic acid or olive oil. The serum concentrations of oleic acid, eicosapentaenoic acid, and apolipoprotein B decreased and those of linoleic acid, gamma-linolenic a...

We have previously determined the dietary a-linolenic requirement for membrane synthesis in the developing animal. This study measures the dietary re quirement for maintaining normal membrane compo sition in adult rats, as determined by 22:6(n-3) (docosahexaenoic acid) concentration. Sixty-day-old rats, previously fed a diet containing both linoleic and a-lino lenic acid, were divided into nine...

Inhibition of Ehrlich ascites carcinoma respiration by aqueous extracts of oxidized linoleic or linolenic acid (aqueous emulsions UV-irradiated, 90 min) was associated entirely with relatively involatile compounds which were both thiobarbituric acid (TBA)-reactive and peroxidase-reactive. Inhibitory compounds were heat stable and migrated in thin-layer chromatography with aldehydes, "hydroperox...

By employing gas chromatography, thefatty acidcontents were determinedin the root, stem,and leaf of A. pseudalhagi.The compositionof fatty acids varied among organs A.pseudalhagi. The unsaturation percentages for each part 47.78%, 48.17%,and 44.12%, respectively. dominant acid in leavesand stems was palmitic acid. contentof these organsvaried from 19.25% to 19.69%. other major γ-linolenic acidi...

Human or rat microsomal 5 alpha-reductase activity, as measured by enzymic conversion of testosterone into 5 alpha-dihydrotestosterone or by binding of a competitive inhibitor, [3H]17 beta-NN-diethulcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one ([3H]4-MA) to the reductase, is inhibited by low concentrations (less than 10 microM) of certain polyunsaturated fatty acids. The relative inhibitory...

Japanese horse chestnut (Aesculus turbinata) seed extract inhibits the activity of cyclooxygenase (COX), but its active constituents have not been identified. In the present study, COX inhibitors were isolated from the hexane extract of this seed by means of 4 steps of liquid chromatography and were identified by gas chromatography/mass spectrometry and nuclear magnetic resonance. The COX inhib...

AA: Arachidonic Acid; ALA: Alfa-Linolenic Acid; ATP: Adult Treatment Panel; BP: Blood Pressure; CVD: Cardiovascular Disease; CRP: C reactive protein; DGLA: Dihomo-γ-Linolenic Acid; DHA: Docosahexaenoic Acid; DPA: Docosapentaenoic Acid; EFA: Essential Fatty Acids; EPA: Eicosapentaenoic Acid; FA: Fatty Acid; GLA -Gama-Linolenic Acid; HDL: High Density Lipoprotein; IL: Interleukine; IR: Insulin Re...

The transfer of fatty acids across biological membranes is a largely uncharacterized process, although it is essential at membranes of several higher plant organelles like chloroplasts, peroxisomes, or the endoplasmic reticulum. Here, we analyzed loss-of-function mutants of the unicellular cyanobacterium Synechocystis sp. PCC 6803 as a model system to circumvent redundancy problems encountered ...