Adipose tissue is a complex, highly metabolically active tissue. The expansion of adipose mainly affected by two processes: the number adipocytes and change adipocyte size. Adipocyte differentiation regulated multiple factors. 3T3-L1 preadipocyte line has become most widely studied cell for proliferation, regulation related genes. In our previous study, we found that ANGPTL4 was to through PPAR...

The low-density lipoprotein receptor (LDLR) pathway is a negative feedback system that plays important roles in the regulation of plasma and intracellular cholesterol homeostasis. To maintain a cholesterol homeostasis, LDLR expression is tightly regulated by sterol regulatory element-binding protein-2 (SREBP-2) and SREBP cleavage-activating protein (SCAP) in transcriptional level and by proprot...

Jasmonates, derivatives of jasmonic acid, are lipid-derived oxylipins with cyclopentanone ring, produced as a result dioxygenation mediated by lipoxygenases. The biosynthesis acid is catalysed series different enzymes, starting from lipoxygenase, allene oxide synthase, cyclase and 12-oxophytodienoic reductase to the final three rounds β-oxidation. Consequently, few metabolites known jasmonates ...

Plasma membrane lipid asymmetry is important for various membrane-associated functions and is regulated by membrane proteins termed flippases and floppases. The Rim101 pathway senses altered lipid asymmetry in the yeast plasma membrane. The mutant lem3Δ cells, in which lipid asymmetry is disturbed owing to the inactivation of the plasma membrane flippases, showed a severe growth defect when the...

With the rapid growth in population and urbanization, a development sustainable treatment of sewage sludge has become an urgent environmental concern globally. Lipid extraction been investigated order to valorize waste through pathway that leads biodiesel. In this work, integrated approach combines lipid with hydrothermal liquefaction lipid-extracted was studied maximize valorization. The proce...

Protein complexes associated to specific membrane lipids and protein-lipid domains contribute to regulate protein sorting and membrane dynamics in the endocytic pathway. It is also becoming apparent that different lipid territories are distributed along the pathway, and that some lipids segregate into specialised microdomains.

Wnt proteins comprise a large class of secreted signaling molecules with key roles during embryonic development and throughout adult life. Recently, much effort has been focused on understanding the factors that regulate Wnt signal production. For example, Porcupine and Wntless/Evi/Sprinter have been identified as being required in Wnt-producing cells for the processing and secretion of many Wn...

Resistance of the weanling rat to acetaminophen (AP AP)-induced hepatotoxicity is manifested with regard to a surge in APAP-glutathione (OSH) conjugate formation in the liver [Allameh et al. Mech Aging Dev 95(1997)71]. The present study was conducted to assess the role of this detoxification pathway in APAPinduced lipid per6xidationin the liver. Lipid peroxidation measured as thiobarbituric...

BACKGROUND Long noncoding RNAs (lncRNAs) are a novel group of universally present, non-coding RNAs (>200 nt) that are increasingly recognized as key regulators of many physiological and pathological processes. SCOPE OF REVIEW Recent publications have shown that lncRNAs influence lipid homeostasis by controlling lipid metabolism in the liver and by regulating adipogenesis. lncRNAs control lipi...

Dairy cows with ketosis displayed lipid metabolic disorder and high inflammatory levels. Adipose tissue is an active lipid metabolism and endocrine tissue and is closely related to lipid metabolism homeostasis and inflammation. Perilipin 1 (PLIN1), an adipocyte-specific lipid-coated protein, may be involved in the above physiological function. The aim of this study is to investigate the role of...