Objective: The current work involves formulation development of nanostructured lipid carrier (NLC) eperisone hydrochloride (EPE) using quality by design (QbD) approach.
 Materials and Methods: Initial screening solid liquid lipids was performed based on the Hansen solubility parameters EPE later confirmed saturation studies. optimum identified three-squared randomized full factorial design...

The aim of this work was to identify from a review current literature the effects lipids used in development Nanostructured Lipid Carriers (NLCs) on physicochemical properties resulting formulation. size solid lipid, affected by molecular weight and complexity structure, tends affect particle final formulation proportionally; higher more complex bigger NLCs. However, there is no straight correl...

Hypertension elevates the risk of heart disease and stroke which are one most frequent causes death. Fortunately, hypertension is manageable with use anti-hypertensives a healthy lifestyle. However, patient non-adherence to prescribed dosing regimen primary reason for uncontrolled blood pressure levels. Daily multiple doses medication major reasons non-compliance regimen. Multiple result low so...

Drugs with low water solubility are predisposed to low and variable oral bioavailability and, therefore, to variability in clinical response. Despite significant efforts to "design in" acceptable developability properties (including aqueous solubility) during lead optimization, approximately 40% of currently marketed compounds and most current drug development candidates remain poorly water-sol...

Here we use nuclear magnetic resonance to measure the solubility limit of several biologically relevant sterols in electroformed giant unilamellar vesicle membranes containing phosphatidylcholine (PC) lipids in ratios of 1:1:X DOPC:DPPC:sterol. We find solubility limits of cholesterol, lanosterol, ergosterol, stigmasterol, and β-sitosterol to be 65-70%, ~35%, 30-35%, 20-25%, and ~40%, respectiv...

PURPOSE Intravenous lipid emulsions have been used to treat the systemic toxicity of local anesthetics. The goal of this in vitro study was to examine the effects of lipid emulsions on the norepinephrine-mediated reversal of vasodilation induced by high doses of levobupivacaine, ropivacaine, and mepivacaine in isolated endothelium-denuded rat aorta, and to determine whether such effects are ass...

Objective: In current research, solid lipid nanoparticles (SLN) are formulated for the anticancer drug, nilotinib, to conquer drawbacks associated with drug including low bioavailability and solubility. Methods: The formulation comprised of tripalmitin (lipid), poloxamer 188(surfactant) glyceryl palmitostearate (cosurfactant) by solvent evaporation technique. process variables SLN were optimize...

Understanding the solubility of nitrogen gas in tissues is a crucial aspect of diving physiology, especially for air-breathing tetrapods. Adipose tissue is of particular interest because of the high solubility of nitrogen in lipids. Surprisingly, nothing is known about nitrogen solubility in the blubber of any marine mammal. We tested the hypothesis that N(2) solubility is dependent on the lipi...

We studied the incorporation of hydrophobic drug Taxol into a solid lipid matrices by FTIR spectroscopy. Lipid arrays containing different molar fractions of the drug were made and deposited on the spectrometer glass window substrates for obtaining multilayer stacks. The drug induced an alteration of lipid array spacings, indicating the drug-lipid recognition. Using excess amounts of Taxol prov...