In an effort to find effective strategies for reducing healthcare costs, the Affordable Care Act has spent billions of dollars on pilot programs. In this paper, I study a Medicare pilot program in New Jersey where hospitals paid doctors bonuses for reducing the total costs of a given admission (a “bundled payment”). I identify the effects of the bonus by comparing the behavior of a given doctor...

The specific activity of acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23) was measured at pH4.5 in normal fibroblasts and in fibroblasts from patients with Farber disease and obligate heterozygotes. Greater activity was found when the synthetically made ceramide substrates contained shorter-chain fatty acids or higher content of double bonds. Acid ceramidase activities towards N-lauro...

Psychiatrists testifying in court have been called charlatans, crooks, or clowns. Some critics have urged that psychiatrists voluntarily absent themselves from the courtroom or be banned from it. I Yet the central question concerning the role of psychiatrists in court revolves around the understanding of the terms "expert" and "justice" and has not been addressed. We do not suggest embracing th...

In order to practice as an occupational therapist, students must complete clinical educational experience as part of their graduation requirements. During this experience, a supervising clinical instructor (CI) provides feedback and guidance that builds the foundation for clinical reasoning skills of the student. The CI-student learning alliance represents the relationship that supports this ed...

The Solt-Farberresistanthepatocyte(RH) and Reddy(dietaryperoxisome proliferato!-) hepatocarcinogenesisprotocolswere utilized to induceboth preneoplasticand neoplasticnodules in male F-344 rats. Totalcellularpolypeptidesfromnormalliver,ciprofibrate(CP)-induced and RH nodules were analyzedfor both qualitativeand quantitative changesusingcomputer-assisted, high resolutiontwo-dimensional pol)acryla...

The patient presented with progressive joint deformity, a hoarse voice, subsequent cachexia, and myoclonic seizures. She was first seen aged 22 months and died aged 6 years. A diagnosis of Farber's disease was made by demonstrating a deficiency of acid ceramidase both in leucocytes and fibroblasts.

In order to practice as an occupational therapist, students must complete clinical educational experience as part of their graduation requirements. During this experience, a supervising clinical instructor (CI) provides feedback and guidance that builds the foundation for clinical reasoning skills of the student. The CI-student learning alliance represents the relationship that supports this ed...

Amorphophallus is a perennial herbaceous plant species mainly distributed in the tropics or subtropics of Asia and Africa. It has been used as a traditional medicine for a long time and now is utilized for the pharmaceutical, chemical and agriculture industries as a valued economic crop. Recently, Amorphophallus has attracted tremendous interest because of its high ceramide content. However, th...

CONTEXT Formalin-fixed paraffin-embedded (FFPE) tissue is a standard for specimen preservation, and as such FFPE tissue banks are an untapped resource of histologically-characterized specimens for retrospective biomarker investigation for pancreatic disease. OBJECTIVES We use liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) to compare FFPE specimens from three different ...