A liquisolid orodispersible tablet of felodipine, a BCS Class II drug, was developed to improve drug dissolution and absorption through the buccal mucosa for management of hypertensive crisis. A 24 full-factorial design was applied to optimize felodipine liquisolid systems (FLSs) having acceptable flow properties and possessing enhanced drug dissolution rates. Four formulation variables; The li...

The basic principle of liquisolid systems formulation lies in the conversion of the drug in a liquid state into an apparently dry, free-flowing and readily compressible powder by its blending (or spraying) with specific carriers and coating materials. The selection of the most suitable carrier and coating material depends especially on their values of flowable liquid retention potential (Φ), wh...

The present work deals with the comparison of in vitro dissolution profiles of fenofibrate liquisolid tablet formulations with those of marketed fenofibrate tablets, and the application of statistical methods to evaluate each method for its usefulness. The methods used to study dissolution profile comparison include Model independent method (Similarity factor, f2); Model dependent methods (Zero...

Department of pharmaceutics, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India. ______________________________________________________________________ ABSTRACT Poorly water-soluble drugs involve many difficulties in the development of pharmaceutical dosage forms for oral delivery systems due to their low bioavailability. Therapeutic effectiveness of a drug depends upon the bioavailabilit...

Liquisolid systems represent an emerging approach in the preparation of solid dosage forms with liquid lipophilic drug or poorly water-soluble solution/suspension suitable vehicle. This study addresses lack data regarding compaction behavior liquisolid systems, aim to investigate influence load, carrier coating ratio, type (microcrystalline cellulose vs. spray dried calcium hydrogen phosphate, ...

it has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. in order to improve the bioavailability, the release behavior of such drugs should be improved. although there are numerous techniques to handle solubility related issue, but they are expensive due to involvement of complicated equipments, advanced m...