نتایج جستجو برای: lithium ascorbate
تعداد نتایج: 55461 فیلتر نتایج به سال:
Rabbits receiving subcutaneous ascorbate after corneal wounding showed significant elevation of aqueous humor ascorbate levels but no enhancement of wound breaking strength when compared to controls. In a second group of rabbits, perilimbal alkali burning reduced aqueous humor ascorbate levels one-half to one-third normal. In these perilimbally burned eyes with wounds in clear cornea, subcutane...
Rationale: The antitumor activity of high-dose ascorbate has been re-evaluated recently, but the mechanism underlying cell-specific sensitivity to ascorbate has not yet been clarified. Methods: The effects of high-dose ascorbate on gastric cancer were assessed using cancer cell lines with high and low expression of GLUT1 via flow cytometry and colony formation assays in vitro and patient-derive...
In an attempt to decrease ascorbate interference on the ion-chromatographic determination of urinary oxalate, we compared the effectiveness of four different methods for ascorbate elimination by analyzing a representative urine pool supplemented with successive ascorbate additions. Two of the methods--treatment with ferric ions or boric acid--have been described elsewhere; treatments with nitri...
2.1. Glutathione 2.1.A. Biological Functions 2.1.B. Biosynthesis 2.1.C. Degradation 2.1.D. Other Thiol-Based Redox Buffers 2.2. Ascorbate 2.2.A. Ascorbate Chemistry 2.2.B. Ascorbate Biosynthesis 2.2.C. Ascorbate Recycling 2.2.D. Ascorbate Transport 2.2.E. Importance of Ascorbate in Stress and Disease 2.3. Other Antioxidants 2.3.A. Lipid-Soluble Antioxidants 2.3.B. Water-Soluble Antioxidants 2.3...
Ascorbate, as a strong and active antioxidant, plays an important role in keeping human health. It helps promote iron absorption, increase antibody concentration and improve human immunity. Ascorbate is used to regenerate a-tocopherol (vitamin E), and remove radicals which could induce cancer and senescence. Ascorbate is beneficial to strengthen blood vessel and decrease cholesterol concentrati...
Hypoxia-inducible factor-1 (HIF-1) governs cellular adaption to the hypoxic microenvironment and is associated with a proliferative, metastatic, and treatment-resistant tumor phenotype. HIF-1 levels and transcriptional activity are regulated by proline and asparagine hydroxylases, which require ascorbate as cofactor. Ascorbate supplementation reduced HIF-1 activation in vitro, but only limited ...
Ascorbate is an antioxidant and coenzyme for various metabolic reactions in vivo. In plant chloroplasts, high ascorbate levels are required to overcome photoinhibition caused by strong light. However, ascorbate is synthesized in the mitochondria and the molecular mechanisms underlying ascorbate transport into chloroplasts are unknown. Here we show that AtPHT4;4, a member of the phosphate transp...
Background: Anaemia has significant impact on health of the fetus as well that mother. Increased need iron during pregnancy especially after 2nd trimester makes supplementation mandatory. Ferrous ascorbate is known to exist intact inside gastrointestinal tract due stable chelation with ascorbate. This compound does not dissociate any food inhibitors. The aim study effectiveness Ascorbate and su...
Oxidation and uptake of ascorbate show similar time courses in rat liver microsomal vesicles: a rapid burst phase is followed by a slower process. Inhibitors of ascorbate oxidation (proadifen, econazole or quercetin) also effectively decreased the uptake of ascorbate. The results show that dehydroascorbate is the transport form of ascorbate at the membrane of the endoplasmic reticulum.
Ascorbate (vitamin C) was an early, unorthodox therapy for cancer, with an outstanding safety profile and anecdotal clinical benefit. Because oral ascorbate was ineffective in two cancer clinical trials, ascorbate was abandoned by conventional oncology but continued to be used in complementary and alternative medicine. Recent studies provide rationale for reexamining ascorbate treatment. Becaus...
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