The monovalent cation lithium, whose introduction in psychiatry dates back at the end of the 1940s, remains the first-line agent in the management of patients with bipolar disorder (BD). It is effective in the treatment of moderate-to-severe acute mania, prophylactic for recurrent manic and depressive episodes, and reduces the risk of suicide. It can also boost antidepressants effects in the tr...

Background: B cell CLL/lymphoma 2 protein, bcl-2, is an important anti-apoptotic factor that has been implicated in lithium’s neuroprotective effect. However, most studies have focused on assessing the effects of lithium in neurons, ignoring examination of bcl-2 in astrocytes, which also influence neuronal survival and are affected in bipolar disorder. The aim of this study was to evaluate whet...

previous studies indicated that endurance exercise decreases levels of liver enzymes. the aim of this study was to determine the effect of endurance exercise on liver enzymes in eight weeks in iranian women who are stopping the drug with methadone. sixty iranian women prisoners including 30 cases as experimental group and 30 volunteers served as control. the mean age, height, weight, percent of...

Bipolar disorder is a major medical, social and economic burden worldwide. However, the biochemical basis of the disorder and the mechanisms of action of effective antibipolar disorder drugs remain elusive. In this paper, we review how combining a kinetic approach to studying the turnover of fatty acids within brain phospholipids of unanesthetized rats along with chronic administration of antim...

Objective(s) It is believed that the mesenchymal stem cell (MSC) differentiation and proliferation are the results of activation of wnt signaling pathway. On the other hand, lithium chloride is reported to be able to activate this pathway. The objective of this study was to investigate the effect of lithium on in vitro proliferation and bone differentiation of marrow-derived MSC. Materials and ...

Electrochemical energy storage systems are categorized into different types, according to their mechanisms, including capacitors, supercapacitors, batteries and fuel cells. All battery systems include some main components: anode, cathode, an aqueous/non-aqueous electrolyte and a membrane that separates anode and cathode while being permeable to ions. Being one of the key parts of any new electr...

Numerous studies have been done on using low serum lithium levels for maintenance therapy of bipolar mood disorder over the past 30-40 years. In this study we sought for the most suitable serum lithium level that having longer relapse's interval periods and less side effects as to recommended it as a maintenance serum lithium level. Thus, we studied 90 patients with bipolar mood disorder (accor...

in this study, the effects of acute and chronic lithium on nociception induced by formalin and its interactions with morphine-induced analgesia were studied in mice. formalin test was selected to study nociception. subcutaneous injection of different doses of morphine (1.5, 3 and 6 mg/kg) induced analgesia in a dose dependent manner in both phases of the formalin test. intraperitoneal administr...

objective: the lithium concentration in the plasma is assumed to give someindication as to the concentration of this ion in different organ cells especially incentral nervous system. while the practical value of intracellular lithium measurement is controversial however, erythrocytes have proved to be useful for studying lithium concentration and its transport across the membrane. there are som...