conclusions we confirmed that serum opg concentrations reduce in obese children. however, no correlation was identified between opg and insulin resistance. opg levels are not meaningful in the diagnosis of nafld in children with obesity. methods this was a prospective, cross-sectional, controlled study that was conducted in the department of pediatrics at bagcilar training and research hospital...

we evaluated the effect of vitamin e and metformin on fatty liver disease in obese children.this interventional study has been done on 119 children with non-alcoholic fatty liver disease (based on sonography results). patients were divided into four treatment groups; they received metformin 1gr daily (age 12 years), vitamin e 800 u daily and vitamin e 400 u daily. liver sonography was performed...

background: the aim of this study was to assess the association between insulin resistance, metabolic syndrome and nonalcoholic fatty liver disease (nafld) in chinese adults. methods: fifty five subjects with nafld and 55 controls were enrolled for the study. waist circumference, blood pressure, plasma triglyceride, high density lipoprotein cholesterol and fasting plasma glucose concentrations ...

background nonalcoholic fatty liver disease has become a worldwide challenge. liver biopsy remains the single most reliable approach to determine the severity of this disease. as patients with nonalcoholic fatty liver disease require close follow-up, performing this invasive method repeatedly seems impractical; therefore, designing a noninvasive system to follow up patients has become a common ...

background genome-wide association studies have shown that rs738491, rs2143571, and rs3761472 in the sorting and assembly machinery component 50 homolog (samm50) gene are significantly associated with susceptibility to nonalcoholic fatty liver disease (nafld). conclusions we first demonstrated that the rs738491 t allele, rs2143571 a allele, and rs3761472 g allele in the samm50 gene created susc...

conclusions this study demonstrated that rt and at are equally effective in reducing hepatic fat content and liver enzyme levels among patients with nafld. however, aerobic exercise specifically improves nafld independent of any change in body weight. results after training, hepatic fat content was markedly reduced, to a similar extent, in both the aerobic and resistance exercise training group...

conclusions decreases in the serum levels of liver aminotransferases and cytokines, in both groups, are related to low-calorie diets and exercise, rather than ptx. results the serum levels of liver aminotransferases were significantly reduced at 3 months and at 6 months, compared with baseline, in both groups. the serum levels of il-6 were significantly decreased, in both groups, only at 6 mont...

Nonalcoholic fatty liver disease (NAFLD) is increasing in pediatric age group parallel to the growing prevalence of obesity and overweight all around the world. So changing in life style and   interventions on obesogenic environment is cornerstone of NAFLD therapy in obese children. Some experts recommend that children and adolescents be encouraged to follow a low-fat, low-glycemic-index diet t...

Background: Metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) is a common public health problem. Visfatin is secreted by visceral adipose tissue and is an adipocytokine. It could be a pro-inflammatory adipocytokine and is related to the metabolic syndrome and non-alcoholic fatty liver disease. This study evaluated the association between visfatin levels in patients w...

background :timely diagnosis of liver cirrhosis is vital for preventing further liver damage and giving the patient the chance of transplantation. although biopsy of the liver is the gold standard for cirrhosis assessment, it has some risks and limitations and this has led to the development of new noninvasive methods to determine the stage and prognosis of the patients. we aimed to design an a...