Six hundred sixty-seven first, second, and third orthotopic liver allografts in 520 patients were reviewed to determine the effect of recipient panel-reactive antibody (PRA) and donor-recipient antibody crossmatch on 2-year patient and liver allograft survival rates. Neither a high panel-reactive antibody nor a positive crossmatch for donor-specific preformed antIbody was associated with decrea...

DOI: 10.1002/jssc.202100066 The cover picture shows a schematic diagram of liquid chromatography with tandem mass spectrometry method for analyzing microsomal and soluble epoxide hydrolase in rat heart, kidney, liver S9 samples. Protein quantification was realized through targeted proteomics the determination trypsin-specific surrogate peptides after digestion. A multiple reaction monitoring po...

cDNA clone for general acyl CoA dehydrogenase (GAD) was isolated from a rat liver cDNA expression library in lambda gt11 using anti-pig kidney GAD antibody. Size of the isolated cDNA was estimated to be 1.5-1.6 kb. By immunological analysis of fusion protein and epitope selection, the cDNA clone was identified as that containing the GAD gene. Partial amino acid sequence deduced from nucleotide ...

It is established that the major protein-synthesizing activity of the liver cell resides in the microsome fraction. This has been shown both by studies in the intact animal and also by incubation of the isolated fraction. More recently evidence has been obtained for the synthesis of serum albumin by such a preparation (Campbell & Kernot, 1962; Sargent & Campbell, 1963). Morphologically the live...

the aim of the present study was to determine the levels of cadmium in the muscle, liver and kidney of cattle from isfahan and to compare the results with those reported by other countries and with the maximum acceptable levels for human consumption. samples of muscle, liver and kidney from 60 animals aged 1–10- year-old were collected from the carcasses slaughtered at isfahan abattoir. samples...

The effects of Buchang Naoxintong Capsules (BNCs) on S-mephenytoin 4'-hydroxylation activities in human liver microsomes in vitro were assessed. Human liver microsome was prepared by different ultracentrifugation. Human liver microsome incubation experiment was carried out to assay BNC on S-mephenytoin 4'-hydroxylation activities. The 4'-hydroxylation of S-mephenytoin, a representative substrat...

tissue metal accumulations (gills, liver, kidney and muscle) in persian sturgeon (acipenser persicus) were compared folowing exposure to sublethal levels of waterborne cd (50, 400 and 1000 μg•l-1) after periods of 1, 2, 4 and 14 days. the obtained results indicate that at the end of 4 and 14 days of exposure, total tissue cadmium concentration followed the pattern: liver > gill > kidney > muscl...

tissue metal accumulations (gills, liver, kidney and muscle) in persian sturgeon (acipenser persicus) were compared folowing exposure to sublethal levels of waterborne cd (50, 400 and 1000 μg•l-1) after periods of 1, 2, 4 and 14 days. the obtained results indicate that at the end of 4 and 14 days of exposure, total tissue cadmium concentration followed the pattern: liver > gill > kidney > muscl...

Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previously reported that the area under the curve ratio of deacetyldiltiazem to diltiazem after oral dosing with diltiazem in rats was sevenfold higher than in humans, the molecular mechanisms underlying th...

results bw was lower for the 5/6 nx group rats after the operations compared with the bw of those in the sham operation group. furthermore, the 5/6 nx group showed elevations in blood pressure, cr, bun, alt, and ast levels compared with the sham group over the course of time. conclusions in summary, ckd induced by the 5/6 nx model caused hypertension and increased serum levels of cr, bun, alt, ...