BACKGROUNDS Antisense oligonucleotide (AO)-mediated exon skipping is the most promising way to express internally deleted dystrophin in Duchenne muscular dystrophy (DMD), by correcting the reading frame of dystrophin mRNA. An antisense chimeric oligonucleotide consisting of 2´-O-methyl RNA and ethylene-bridged nucleic acid (ENA), targeting exon 45 of the dystrophin gene, AO85, has been shown to...

An analytical cross-sectional study was conducted in a public university in Kuala Lumpur among a random sample of 2665 undergraduates. The objective was to study the prevalence of breakfast skipping and its associated factors. Data collection was conducted via a self-administered pre-tested questionnaire. There were 43.5% male respondents, with Malays being the majority (58.3%). The prevalence ...

We introduce skipping refinement, a new notion of correctness for reasoning about optimized reactive systems. Reasoning about reactive systems using refinement involves defining an abstract, highlevel specification system and a concrete, low-level implementation system. One then shows that every behavior allowed by the implementation is also allowed by the specification. Due to the difference i...

Duchenne muscular dystrophy (DMD) is one of the most common lethal genetic diseases worldwide, caused by mutations in the dystrophin (DMD) gene. Exon skipping employs short DNA/RNA-like molecules called antisense oligonucleotides (AONs) that restore the reading frame and produce shorter but functional proteins. However, exon skipping therapy faces two major hurdles: limited applicability (up to...

Deep neural network (DNN) based speech enhancement models have attracted extensive attention due to their promising performance. However, it is difficult deploy a powerful DNN in real-time applications because of its high computational cost. Typical compression methods such as pruning and quantization do not make good use the data characteristics. In this paper, we introduce Skip-RNN strategy i...

background: this study aimed to assess the relationship between meal frequency with mental distress and violent behavior among a nationally representative sample of iranian children and adolescents. materials and methods: the participants of this national study were 14,880 iranian students with 6 to 18 years of age. they were selected from urban and rural regions of iran by multi-stage cluster ...